Skip to main content
PMC home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1981 Feb;65(2):138–141. doi: 10.1136/bjo.65.2.138

Iris neovascularisation in eyes with pseudoexfoliation syndrome.

A Ringvold, M Davanger
PMCID: PMC1039443  PMID: 6161638

Abstract

The iris vascular bed of eyes with pseudoexfoliation syndrome has been studied with electron microscopy. Two of the eyes suffered from painful glaucoma, whereas the third showed normal intraocular pressure. The following changes were observed: (1) deposits of pseudoexfoliation material lying adjacent to the endothelial wall; (2) thin vessel basement membrane, sometimes even interrupted; (3) extreme reduction of vessel lumina through increased volume of the endothelial cells; (4) fenestration of the endothelial wall. It is suggested that the iris neovascularisation in eyes with pseudoexfoliation syndrome is due to an obstruction of iris vessels causing tissue hypoxia.

Full text

PDF
138

Images in this article

139Image
on p.139
140Image
on p.140
140Image
on p.140

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DVORAK-THEOBALD G. Pseudo-exfoliation of the lens capsule: relation to true exfoliation of the lens capsule as reported in the literature and role in the production of glaucoma capsulocuticulare. Am J Ophthalmol. 1954 Jan;37(1):1–12. [PubMed] [Google Scholar]
  2. Friederici H. H., Taylor H., Rose R., Pirani C. L. The fine structure of capillaries in experimental scurvy. Lab Invest. 1966 Sep;15(9):1442–1458. [PubMed] [Google Scholar]
  3. Gartner S., Henkind P. Neovascularization of the iris (rubeosis iridis). Surv Ophthalmol. 1978 Mar-Apr;22(5):291–312. doi: 10.1016/0039-6257(78)90175-3. [DOI] [PubMed] [Google Scholar]
  4. Gimbrone M. A., Jr, Leapman S. B., Cotran R. S., Folkman J. Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst. 1973 Jan;50(1):219–228. doi: 10.1093/jnci/50.1.219. [DOI] [PubMed] [Google Scholar]
  5. Goldberg M. F., Tso M. O. Rubeosis iridis and glaucoma associated with sickle cell retinopathy: a light and electron microscopic study. Ophthalmology. 1978 Oct;85(10):1028–1041. doi: 10.1016/s0161-6420(78)35587-1. [DOI] [PubMed] [Google Scholar]
  6. Gore I., Wada M., Goodman M. L. Capillary hemorrhage in ascorbic-acid-deficient guinea pigs. Ultrastructural basis. Arch Pathol. 1968 May;85(5):493–502. [PubMed] [Google Scholar]
  7. Henkind P. Ocular neovascularization. The Krill memorial lecture. Am J Ophthalmol. 1978 Mar;85(3):287–301. [PubMed] [Google Scholar]
  8. Okamura R., Rohen J. W. Elektronenmikroskopische Untersuchungen über die Rubeosis iridis. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1971;182(1):53–75. doi: 10.1007/BF00406518. [DOI] [PubMed] [Google Scholar]
  9. Ringvold A. Electron microscopy of the wall of iris vessels in eyes with and without exfoliation syndrome (pseudoexfoliation of the lens capsule). Virchows Arch A Pathol Pathol Anat. 1969;348(4):328–341. doi: 10.1007/BF00548526. [DOI] [PubMed] [Google Scholar]
  10. Ringvold A. The distribution of the exfoliation material in the iris from eyes with exfoliation syndrome (pseudoexfoliation of the lens capsule). Virchows Arch A Pathol Pathol Anat. 1970;351(2):168–178. doi: 10.1007/BF00542941. [DOI] [PubMed] [Google Scholar]
  11. SAMPAOLESI R. Note sur la diffusion de la fluoréscine dans le corps vitré. Ophthalmologica. 1956 Apr-May;131(4-5):359–364. doi: 10.1159/000302863. [DOI] [PubMed] [Google Scholar]
  12. SCHOEFL G. I. STUDIES ON INFLAMMATION. III. GROWING CAPILLARIES: THEIR STRUCTURE AND PERMEABILITY. Virchows Arch Pathol Anat Physiol Klin Med. 1963 Nov 8;337:97–141. [PubMed] [Google Scholar]
  13. Schulze R. R. Rubeosis iridis. Am J Ophthalmol. 1967 Mar;63(3):487–495. doi: 10.1016/0002-9394(67)90249-8. [DOI] [PubMed] [Google Scholar]
  14. Sosula L., Beaumont P., Hollows F. C., Jonson K. M. Dilatation and endothelial proliferation of retinal capillaries in streptozotocin-diabetic rats: quantitative electron microscopy. Invest Ophthalmol. 1972 Nov;11(11):926–935. [PubMed] [Google Scholar]
  15. Sugar H. S., Harding C., Barsky D. The exfoliation syndrome. Ann Ophthalmol. 1976 Oct;8(10):1165–1181. [PubMed] [Google Scholar]
  16. Vegge T., Ringvold A. Ultrastructure of the wall of human iris vessels. Z Zellforsch Mikrosk Anat. 1969;94(1):19–31. doi: 10.1007/BF00335184. [DOI] [PubMed] [Google Scholar]
  17. Wallow I. H., Engerman R. L. Permeability and patency of retinal blood vessels in experimental diabetes. Invest Ophthalmol Vis Sci. 1977 May;16(5):447–461. [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES