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. 1981 Apr;65(4):252–257. doi: 10.1136/bjo.65.4.252

Decompensation of chronic open-angle glaucoma following mydriasis-induced pigmentary dispersion into the aqueous humour: a light and electron microscopic study.

R Haddad, G Strasser, P Heilig, W Jurecka
PMCID: PMC1039493  PMID: 7236569

Abstract

A patient with well controlled chronic open-angle glaucoma developed after dilatation of both pupils persistent increase in intraocular pressure (IOP) due to extensive pigmentary dispersion into the aqueous humour. Trabeculectomy specimens obtained from both eyes after 3 and 7 weeks were studied by light and electron microscopy. It seems evident that the initial phase of raised IOP was caused by a clogging mechanism to the outflow channels by melanin and phagocytic cells. The permanent increase in IOP is attributed to the damage induced in the fibrous components of the trabecular sheets as a result of a complete breakdown of their endothelial covering.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bill A. Editorial: The drainage of aqueous humor. Invest Ophthalmol. 1975 Jan;14(1):1–3. [PubMed] [Google Scholar]
  2. Epstein D. L., Boger W. P., 3rd, Grant W. M. Phenylephrine provocative testing in the pigmentary dispersion syndrome. Am J Ophthalmol. 1978 Jan;85(1):43–50. doi: 10.1016/s0002-9394(14)76663-2. [DOI] [PubMed] [Google Scholar]
  3. FENTON R. H., ZIMMERMAN L. E. HEMOLYTIC GLAUCOMA. AN UNUSUAL CAUSE OF ACUTE OPEN-ANGLE SECONDARY GLAUCOMA. Arch Ophthalmol. 1963 Aug;70:236–239. doi: 10.1001/archopht.1963.00960050238015. [DOI] [PubMed] [Google Scholar]
  4. FLOCKS M., LITTWIN C. S., ZIMMERMAN L. E. Phacolytic glaucoma; a clinicopathologic study of one hundred thirty-eight cases of glaucoma associated with hypermature cataract. AMA Arch Ophthalmol. 1955 Jul;54(1):37–45. [PubMed] [Google Scholar]
  5. Grierson I., Chisholm I. A. Clearance of debris from the iris through the drainage angle of the rabbit's eye. Br J Ophthalmol. 1978 Oct;62(10):694–704. doi: 10.1136/bjo.62.10.694. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Grierson I., Lee W. R. Erythrocyte phagocytosis in the human trabecular meshwork. Br J Ophthalmol. 1973 Jun;57(6):400–415. doi: 10.1136/bjo.57.6.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Grierson I., Lee W. R. Further observations on the process of haemophagocytosis in the human outflow system. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 8;208(1-3):49–64. doi: 10.1007/BF00406981. [DOI] [PubMed] [Google Scholar]
  8. Hoffmann F., Dumitrescu L., Hager H. Pigmentglaukom (Rasterelektronenmikroskopische Befunde) Klin Monbl Augenheilkd. 1975 May;166(5):609–613. [PubMed] [Google Scholar]
  9. Iwamoto T., Witmer R., Landolt E. Light and electron microscopy in absolute glaucoma with pigment dispersion phenomena and contusion angle deformity. Am J Ophthalmol. 1971 Aug;72(2):420–434. doi: 10.1016/0002-9394(71)91315-8. [DOI] [PubMed] [Google Scholar]
  10. Kristensen P. Mydriasis-induced pigment liberation in the anterior chamber associated with acute rise in intraocular pressure in open-angle glaucoma. Acta Ophthalmol (Copenh) 1965;43(5):714–724. doi: 10.1111/j.1755-3768.1965.tb00343.x. [DOI] [PubMed] [Google Scholar]
  11. Lee W. R. The study of the passage of particles through the endothelium of the outflow apparatus of the monkey eye by scanning and transmission electron microscopy. Trans Ophthalmol Soc U K. 1971;91:687–705. [PubMed] [Google Scholar]
  12. MITSUI Y., TAKAGI Y. Nature of aqueous floaters due to sympathomimetic mydriatics. Arch Ophthalmol. 1961 May;65:626–631. doi: 10.1001/archopht.1961.01840020628004. [DOI] [PubMed] [Google Scholar]
  13. ROHEN J., UNGER H. H. Studies on the morphology and pathology of the trabecular meshwork in the human eye. Am J Ophthalmol. 1958 Dec;46(6):802–813. doi: 10.1016/0002-9394(58)90991-7. [DOI] [PubMed] [Google Scholar]
  14. Richardson T. M., Hutchinson B. T., Grant W. M. The outflow tract in pigmentary glaucoma: a light and electron microscopic study. Arch Ophthalmol. 1977 Jun;95(6):1015–1025. doi: 10.1001/archopht.1977.04450060101010. [DOI] [PubMed] [Google Scholar]
  15. Ringvold A., Vegge T. Electron microscopy of the trabecular meshwork in eyes with exfoliation syndrome. (Pseudoexfoliation of the lens capsule). Virchows Arch A Pathol Pathol Anat. 1971;353(2):110–127. doi: 10.1007/BF00548971. [DOI] [PubMed] [Google Scholar]
  16. Rodrigues M. M., Spaeth G. L., Weinreb S., Sivalingam E. Spectrum of trabecular pigmentation in open-angle glaucoma: a clinicopathologic study. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Mar-Apr;81(2):258–276. [PubMed] [Google Scholar]
  17. Rohen J. W., van der Zypen E. The phagocytic activity of the trabecularmeshwork endothelium. An electron-microscopic study of the vervet (Cercopithecus aethiops). Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1968;175(2):143–160. doi: 10.1007/BF02385060. [DOI] [PubMed] [Google Scholar]
  18. Roth M., Epstein D. L. Exfoliation syndrome. Am J Ophthalmol. 1980 Apr;89(4):477–481. doi: 10.1016/0002-9394(80)90054-9. [DOI] [PubMed] [Google Scholar]
  19. Shabo A. L., Maxwell D. S. Observations on the fate of blood in the anterior chamber. A light and electron microscopic study of the monkey trabecular meshwork. Am J Ophthalmol. 1972 Jan;73(1):25–36. doi: 10.1016/0002-9394(72)90300-5. [DOI] [PubMed] [Google Scholar]
  20. Tripathi R. C. Aqueous outflow pathway in normal and glaucomatous eyes. Br J Ophthalmol. 1972 Mar;56(3):157–174. doi: 10.1136/bjo.56.3.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Yanoff M., Scheie H. G. Melanomalytic glaucoma. Report of a case. Arch Ophthalmol. 1970 Oct;84(4):471–473. doi: 10.1001/archopht.1970.00990040473013. [DOI] [PubMed] [Google Scholar]

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