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. 1981 Jul;65(7):494–502. doi: 10.1136/bjo.65.7.494

Ocular changes with oral and transepidermal diethylcarbamazine therapy of onchocerciasis.

H R Taylor, B M Greene
PMCID: PMC1039557  PMID: 7020746

Abstract

Twenty men with moderate infection of Onchocerca volvulus were studied in a double-masked, controlled clinical trial to compare the safety and efficacy of oral diethylcarbamazine (DEC) with topical DEC lotion. Visual acuity and colour vision did not alter during the 6 months of observation, although 2 patients receiving DEC lotion and 3 patients receiving oral DEC developed either visual field constriction or optic atrophy. Fluffy corneal opacities were common in both groups. Intraocular microfilariae also appeared in both groups but to a greater extent in those receiving DEC lotion. New chorioretinal changes developed in 4 men receiving lotion and in only 1 receiving tablets. It is concluded that DEC lotion offers no advantage over tablets in the treatment of ocular onchocerciasis and in fact may be associated with more ocular complications than the conventional oral treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J., Fuglsang H. Further studies on the treatment of ocular onchocerciasis with diethylcarbamazine and suramin. Br J Ophthalmol. 1978 Jul;62(7):450–457. doi: 10.1136/bjo.62.7.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson J., Fuglsang H., de C Marshall T. F. Effects of diethylcarbamazine on ocular onchocerciasis. Tropenmed Parasitol. 1976 Sep;27(3):263–278. [PubMed] [Google Scholar]
  3. Anderson J., Fuglsang H., de C Marshall T. F. Effects of suramin on ocular onchocerciasis. Tropenmed Parasitol. 1976 Sep;27(3):279–296. [PubMed] [Google Scholar]
  4. Berghout E. Onchocerciasis and glaucoma in the forest area of Ghana. Trop Geogr Med. 1973 Sep;25(3):233–237. [PubMed] [Google Scholar]
  5. Bird A. C., el-Sheikh H., Anderson J., Fuglsang H. Changes in visual function and in the posterior segment of the eye during treatment of onchocerciasis with diethylcarbamazine citrate. Br J Ophthalmol. 1980 Mar;64(3):191–200. doi: 10.1136/bjo.64.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Garner A. Pathology of ocular onchocerciasis: human and experimental. Trans R Soc Trop Med Hyg. 1976;70(5-6):374–377. doi: 10.1016/0035-9203(76)90113-9. [DOI] [PubMed] [Google Scholar]
  7. Greene B. M., Taylor H. R., Humphrey R. L. Proteinuria associated with diethylcarbamazine treatment of onchocerciasis. Lancet. 1980 Feb 2;1(8162):254–255. doi: 10.1016/s0140-6736(80)90737-0. [DOI] [PubMed] [Google Scholar]
  8. Hawking F. Diethylcarbamazine and new compounds for the treatment of filariasis. Adv Pharmacol Chemother. 1979;16:129–194. doi: 10.1016/s1054-3589(08)60244-6. [DOI] [PubMed] [Google Scholar]
  9. Jones B. R., Anderson J., Fuglsang H. Effects of various concentrations of diethylcarbamazine citrate applied as eye drops in ocular onchocerciasis, and the possibilities of improved therapy from continuous non-pulsed delivery. Br J Ophthalmol. 1978 Jul;62(7):428–439. doi: 10.1136/bjo.62.7.428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Langham M. E. Diethylcarbamazine lotion in onchocerciasis. Lancet. 1980 May 3;1(8175):977–978. doi: 10.1016/s0140-6736(80)91420-8. [DOI] [PubMed] [Google Scholar]
  11. Langham M. E., Traub Z. D., Richardson R. A transepidermal chemotherapy of onchocerciasis. Tropenmed Parasitol. 1978 Jun;29(2):156–162. [PubMed] [Google Scholar]
  12. Taylor H. R., Greene B. M., Langham M. E. Controlled clinical trial of oral and topical diethylcarbamazine in treatment of onchocerciasis. Lancet. 1980 May 3;1(8175):943–946. doi: 10.1016/s0140-6736(80)91402-6. [DOI] [PubMed] [Google Scholar]
  13. Taylor H. R., Langham M. E., de Stahl E. M., Figueroa L. N., Beltranena F. Chemotherapy of onchocerciasis: a controlled clinical trial of topical diethylcarbamazine (DEC) in Guatemala. Tropenmed Parasitol. 1980 Sep;31(3):357–364. [PubMed] [Google Scholar]
  14. Thylefors B., Brinkmann U. K. The microfilarial load in the anterior segment of the eye. A parameter of intensity of onchocerciasis. Bull World Health Organ. 1977;55(6):731–737. [PMC free article] [PubMed] [Google Scholar]
  15. Thylefors B., Duppenthaler J. L. Epidemiological aspects of intraocular pressure in an onchocerciasis endemic area. Bull World Health Organ. 1979;57(6):963–969. [PMC free article] [PubMed] [Google Scholar]
  16. Thylefors B., Rolland A. The risk of optic atrophy following suramin treatment of ocular onchocerciasis. Bull World Health Organ. 1979;57(3):479–480. [PMC free article] [PubMed] [Google Scholar]
  17. Thylefors B., Tønjum A. M. Visual field defects in onchocerciasis. Br J Ophthalmol. 1978 Jul;62(7):462–467. doi: 10.1136/bjo.62.7.462. [DOI] [PMC free article] [PubMed] [Google Scholar]

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