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. 1981 Sep;65(9):626–630. doi: 10.1136/bjo.65.9.626

Amino acids in retinitis pigmentosa.

S A Arshinoff, J C McCulloch, W Macrae, A N Stein, E B Marliss
PMCID: PMC1039610  PMID: 7295629

Abstract

A survey of fasting whole blood amino acids in 65 patients with various subtypes of retinitis pigmentosa performed. Eight X-linked recessive patients showed decreased taurine and aspartate. Nineteen autosomal recessive patients, and to lesser extent 10 autosomal dominant patients, showed reduced levels of whole blood threonine and histidine. Branched-chain amino acids and arginine were present in increased amounts in 2 patients with Laurence-Moon-Bardet-Biedl syndrome. These findings in LMBB patients are probably related in part to their obesity and emphasise that appropriate controls are required, and other factors (including age) known to affect amino acid levels must be accounted for. The biochemical implications of our findings are not yet apparent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Airaksinen E. M., Sihvola P., Airaksinen M. M., Sihvola M., Tuovinen E. Uptake of taurine by platelets in retinitis pigmentosa. Lancet. 1979 Mar 3;1(8114):474–475. doi: 10.1016/s0140-6736(79)90826-2. [DOI] [PubMed] [Google Scholar]
  2. Arshinoff S. A., McCulloch J. C., Matuk Y., Phillips M. J., Gordon B. A., Marliss E. B. Amino-acid metabolism and liver ultrastructure in hyperornithinemia with gyrate atrophy of the choroid and retina. Metabolism. 1979 Oct;28(10):979–988. doi: 10.1016/0026-0495(79)90001-5. [DOI] [PubMed] [Google Scholar]
  3. Berson E. L., Schmidt S. Y., Rabin A. R. Plasma amino-acids in hereditary retinal disease. Ornithine, lysine, and taurine. Br J Ophthalmol. 1976 Feb;60(2):142–147. doi: 10.1136/bjo.60.2.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Campbell D. A., Tonks E. L. BIOCHEMICAL FINDINGS IN HUMAN RETINITIS PIGMENTOSA WITH PARTICULAR RELATION TO VITAMIN A DEFICIENCY. Br J Ophthalmol. 1962 Mar;46(3):151–164. doi: 10.1136/bjo.46.3.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Felig P., Marliss E., Cahill G. F., Jr Plasma amino acid levels and insulin secretion in obesity. N Engl J Med. 1969 Oct 9;281(15):811–816. doi: 10.1056/NEJM196910092811503. [DOI] [PubMed] [Google Scholar]
  6. Fujiwara H. [Biochemical studies on retinitis pigmentosa. 3. Study on amino acid metabolism of patients with retinitis pigmentosa]. Nihon Ganka Kiyo. 1968 Jul;19(7):741–753. [PubMed] [Google Scholar]
  7. Marliss E. B., Murray F. T., Nakhooda A. F. The metabolic response to hypocaloric protein diets in obese man. J Clin Invest. 1978 Aug;62(2):468–479. doi: 10.1172/JCI109148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McCulloch J. C., Arshinoff S. A., Marliss E. B., Parker J. A. Hyperornithinemia and gyrate atrophy of the choroid and retina. Ophthalmology. 1978 Sep;85(9):918–928. doi: 10.1016/s0161-6420(78)35598-6. [DOI] [PubMed] [Google Scholar]
  9. McInnes R. R., Arshinoff S. A., Bell L., Marliss E. B., McCulloch J. C. Hyperornithinaemia and gyrate atrophy of the retina: improvement of vision during treatment with a low-arginine diet. Lancet. 1981 Mar 7;1(8219):513–516. doi: 10.1016/s0140-6736(81)92858-0. [DOI] [PubMed] [Google Scholar]
  10. Schmidt S. Y., Berson E. L., Hayes K. C. Retinal degeneration in cats fed casein. I. Taurine deficiency. Invest Ophthalmol. 1976 Jan;15(1):47–52. [PubMed] [Google Scholar]

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