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. 1982 Mar;66(3):165–169. doi: 10.1136/bjo.66.3.165

A low-molecular-weight angiogenic factor in cat retina.

R D Kissun, C R Hill, A Garner, P Phillips, S Kumar, J B Weiss
PMCID: PMC1039745  PMID: 7066267

Abstract

A low-molecular-weight angiogenic factor has been isolated from healthy adult cat retinas. The factor, which has been purified by diethylaminoethyl (DEAE) cellulose chromatography and affinity chromatography, stimulates neovascularisation of the chick chorioallantoic membrane and has a number of properties similar to those previously described for a tumour factor. The finding of an angiogenic factor in healthy retina and its relationship to previously described inhibitors of angiogenesis is discussed.

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Selected References

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  1. ASHTON N. Retinal vascularization in health and disease: Proctor Award Lecture of the Association for Research in Ophthalmology. Am J Ophthalmol. 1957 Oct;44(4 Pt 2):7–17. doi: 10.1016/0002-9394(57)90426-9. [DOI] [PubMed] [Google Scholar]
  2. Brem S., Brem H., Folkman J., Finkelstein D., Patz A. Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Cancer Res. 1976 Aug;36(8):2807–2812. [PubMed] [Google Scholar]
  3. Brown R. A., Weiss J. B., Tomlinson I. W., Phillips P., Kumar S. Angiogenic factor from synovial fluid resembling that from tumours. Lancet. 1980 Mar 29;1(8170):682–685. [PubMed] [Google Scholar]
  4. Chen C. H., Chen S. C. Angiogenic activity of vitreous and retinal extract. Invest Ophthalmol Vis Sci. 1980 Jun;19(6):596–602. [PubMed] [Google Scholar]
  5. D'Amore P. A., Glaser B. M., Brunson S. K., Fenselau A. H. Angiogenic activity from bovine retina: partial purification and characterization. Proc Natl Acad Sci U S A. 1981 May;78(5):3068–3072. doi: 10.1073/pnas.78.5.3068. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Federman J. L., Brown G. C., Felberg N. T., Felton S. M. Experimental ocular angiogenesis. Am J Ophthalmol. 1980 Feb;89(2):231–237. doi: 10.1016/0002-9394(80)90116-6. [DOI] [PubMed] [Google Scholar]
  7. Felton S. M., Brown G. C., Felberg N. T., Federman J. L. Vitreous inhibition of tumor neovascularization. Arch Ophthalmol. 1979 Sep;97(9):1710–1713. doi: 10.1001/archopht.1979.01020020278019. [DOI] [PubMed] [Google Scholar]
  8. Folkman J., Merler E., Abernathy C., Williams G. Isolation of a tumor factor responsible for angiogenesis. J Exp Med. 1971 Feb 1;133(2):275–288. doi: 10.1084/jem.133.2.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Glaser B. M., D'Amore P. A., Michels R. G., Brunson S. K., Fenselau A. H., Rice T., Patz A. The demonstration of angiogenic activity from ocular tissues. Preliminary report. Ophthalmology. 1980 May;87(5):440–446. doi: 10.1016/s0161-6420(80)35224-x. [DOI] [PubMed] [Google Scholar]
  10. Glaser B. M., D'Amore P. A., Michels R. G., Patz A., Fenselau A. Demonstration of vasoproliferative activity from mammalian retina. J Cell Biol. 1980 Feb;84(2):298–304. doi: 10.1083/jcb.84.2.298. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Goldberg M. F. Classification and pathogenesis of proliferative sickle retinopathy. Am J Ophthalmol. 1971 Mar;71(3):649–665. doi: 10.1016/0002-9394(71)90429-6. [DOI] [PubMed] [Google Scholar]
  12. Henkind P. Ocular neovascularization. The Krill memorial lecture. Am J Ophthalmol. 1978 Mar;85(3):287–301. [PubMed] [Google Scholar]
  13. Jampol L. M., Goldbaum M. H. Peripheral proliferative retinopathies. Surv Ophthalmol. 1980 Jul-Aug;25(1):1–14. doi: 10.1016/0039-6257(80)90071-5. [DOI] [PubMed] [Google Scholar]
  14. Kissun R. D., Garner A. Vasoformative properties of normal and hypoxic retinal tissue. Br J Ophthalmol. 1977 Jun;61(6):394–398. doi: 10.1136/bjo.61.6.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Krill A. E., Archer D., Newell F. W. Photocoagulation in complications secondary to branch vein occlusion. Arch Ophthalmol. 1971 Jan;85(1):48–60. doi: 10.1001/archopht.1971.00990050050008. [DOI] [PubMed] [Google Scholar]
  16. McAuslan B. R., Hoffman H. Endothelium stimulating factor from Walker carcinoma cells. Relation to tumor angiogenic factor. Exp Cell Res. 1979 Mar 1;119(1):181–190. doi: 10.1016/0014-4827(79)90347-1. [DOI] [PubMed] [Google Scholar]
  17. Phillips P., Kumar S. Tumour angiogenesis factor (TAF) and its neutralisation by a xenogeneic antiserum. Int J Cancer. 1979 Jan 15;23(1):82–88. doi: 10.1002/ijc.2910230115. [DOI] [PubMed] [Google Scholar]
  18. Preis I., Langer R., Brem H., Folkman J. Inhibition of neovascularization by an extract derived from vitreous. Am J Ophthalmol. 1977 Sep;84(3):323–328. doi: 10.1016/0002-9394(77)90672-9. [DOI] [PubMed] [Google Scholar]
  19. WISE G. N. Retinal neovascularization. Trans Am Ophthalmol Soc. 1956;54:729–826. [PMC free article] [PubMed] [Google Scholar]
  20. Weiss J. B., Brown R. A., Kumar S., Phillips P. An angiogenic factor isolated from tumours: a potent low-molecular-weight compound. Br J Cancer. 1979 Sep;40(3):493–496. doi: 10.1038/bjc.1979.206. [DOI] [PMC free article] [PubMed] [Google Scholar]

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