Abstract
Eight commercial topical anaesthetic preparations were tested for their ability to inhibit microbial growth in vitro by incubating serial dilutions with each of 4 micro-organisms. In addition corneas of mice were infected with Staphylococcus aureus, and the effect of the anaesthetics on isolation rates of bacteria was investigated. The preparations were shown to have a wide range of antimicrobial activity, correlating both with the active agents and the preservatives. We suggest that some preparations are unsuitable for use prior to collection of specimens from human corneal ulcers.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CONTE B. A., LAFORET E. G. The role of the topical anesthetic agent in modifying bacteriologic data obtained by bronchoscopy. N Engl J Med. 1962 Nov 8;267:957–960. doi: 10.1056/NEJM196211082671903. [DOI] [PubMed] [Google Scholar]
- ERLICH H. Bacteriologic studies and effects of anesthetic solutions on bronchial secretions during bronchoscopy. Am Rev Respir Dis. 1961 Sep;84:414–421. doi: 10.1164/arrd.1961.84.3.414. [DOI] [PubMed] [Google Scholar]
- Kleinfeld J., Ellis P. P. Effects of topical anesthetics on growth of microorganisms. Arch Ophthalmol. 1966 Nov;76(5):712–715. doi: 10.1001/archopht.1966.03850010714017. [DOI] [PubMed] [Google Scholar]
- Schmidt R. M., Rosenkranz H. S. Antimicrobial activity of local anesthetics: lidocaine and procaine. J Infect Dis. 1970 Jun;121(6):597–607. doi: 10.1093/infdis/121.6.597. [DOI] [PubMed] [Google Scholar]
- Weinstein M. P., Maderazo E., Tilton R., Maggini G., Quintiliani R. Further observations on the antimicrobial effects of local anesthetic agents. Curr Ther Res Clin Exp. 1975 Apr;17(4):369–374. [PubMed] [Google Scholar]