Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1982 Jul;66(7):450–454. doi: 10.1136/bjo.66.7.450

Solitary extramedullary plasmacytoma of the palpebral conjunctiva.

J M Seddon, J M Corwin, J J Weiter, J U Brisbane, F C Sutula
PMCID: PMC1039821  PMID: 7093184

Abstract

A 63-year-old man had a solitary extramedullary plasmacytoma of the conjunctiva for several years with no history of ocular inflammation or systemic abnormalities. Immunoperoxidase staining was consistent with a neoplastic lesion. This is the only well documented such case in the recent literature to the best of our knowledge. This rare condition is contrasted with reactive plasma cell granuloma, a benign inflammatory condition, which comprises most of the cases previously reported as plasmacytomas. Since extraskeletal plasmacytomas may be the first manifestation of multiple myeloma, these patients deserve appropriate diagnostic evaluation and close follow-up.

Full text

PDF
450

Images in this article

451Image
on p.451
451Image
on p.451
452Image
on p.452

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexanian R. Plasma cell neoplasms. CA Cancer J Clin. 1976 Jan-Feb;26(1):38–49. doi: 10.3322/canjclin.26.1.38. [DOI] [PubMed] [Google Scholar]
  2. Bahadori M., Liebow A. A. Plasma cell granulomas of the lung. Cancer. 1973 Jan;31(1):191–208. doi: 10.1002/1097-0142(197301)31:1<191::aid-cncr2820310127>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  3. Benjamin I., Taylor H., Spindler J. Orbital and conjunctival involvement in multiple myeloma. Report of a case. Am J Clin Pathol. 1975 Jun;63(6):811–817. doi: 10.1093/ajcp/63.6.811. [DOI] [PubMed] [Google Scholar]
  4. Bhargava S., Gupta M. C., Vyas K., Saxena B. P. Solitary plasmocytoma of conjunctiva. J All India Ophthalmol Soc. 1967 Feb;15(1):38–39. [PubMed] [Google Scholar]
  5. CLARKE E. Plasma cell myeloma of the orbit. Br J Ophthalmol. 1953 Sep;37(9):543–554. doi: 10.1136/bjo.37.9.543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. COGAN J. F. Extramedullary plasmocytoma of the orbit; observations on two cases. Br J Ophthalmol. 1956 Nov;40(11):681–685. doi: 10.1136/bjo.40.11.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Canlas M. S., Dillon M. L., Loughrin J. J. Primary cutaneous plasmacytoma. Report of a case and review of the literature. Arch Dermatol. 1979 Jun;115(6):722–724. doi: 10.1001/archderm.115.6.722. [DOI] [PubMed] [Google Scholar]
  8. Conklin R., Alexanian R. Clinical classification of plasma cell myeloma. Arch Intern Med. 1975 Jan;135(1):139–143. [PubMed] [Google Scholar]
  9. Corwin J., Lindberg R. D. Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer. 1979 Mar;43(3):1007–1013. doi: 10.1002/1097-0142(197903)43:3<1007::aid-cncr2820430333>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  10. DOLIN S., DEWAR J. P. Extramedullary plasmacytoma. Am J Pathol. 1956 Jan-Feb;32(1):83–103. [PMC free article] [PubMed] [Google Scholar]
  11. Fu Y. S., Perzin K. H. Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx. A clinicopathologic study. IX. Plasmacytomas. Cancer. 1978 Nov;42(5):2399–2406. doi: 10.1002/1097-0142(197811)42:5<2399::aid-cncr2820420541>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  12. Jampol L. M., Marsh J. C., Albert D. M., Zimmerman L. E. IgA associated lymphoplasmacytic tumor involving the conjunctiva, eyelid, and orbit. Am J Ophthalmol. 1975 Feb;79(2):279–284. doi: 10.1016/0002-9394(75)90082-3. [DOI] [PubMed] [Google Scholar]
  13. Kyle R. A. Monoclonal gammopathy of undetermined significance. Natural history in 241 cases. Am J Med. 1978 May;64(5):814–826. doi: 10.1016/0002-9343(78)90522-3. [DOI] [PubMed] [Google Scholar]
  14. Mathur S. P. CONJUNCTIVAL PLASMOMA. Br J Ophthalmol. 1959 Aug;43(8):499–500. doi: 10.1136/bjo.43.8.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mewis-Levin L., Garcia C. A., Olson J. D. Plasma cell myeloma of the orbit. Ann Ophthalmol. 1981 Apr;13(4):477–481. [PubMed] [Google Scholar]
  16. NELSON M. G., LYONS A. R. Plasmacytoma of lymph glands. Cancer. 1957 Nov-Dec;10(6):1275–1280. doi: 10.1002/1097-0142(195711/12)10:6<1275::aid-cncr2820100625>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  17. Pahor A. L. Extramedullary plasmacytoma of the head and neck, parotid and submandibular salivary glands. J Laryngol Otol. 1977 Mar;91(3):241–258. doi: 10.1017/s0022215100083626. [DOI] [PubMed] [Google Scholar]
  18. Rao N. A., Font R. L. Plasmacytic conjunctivitis with crystalline inclusions. Immunohistochemical and ultrastructural studies. Arch Ophthalmol. 1980 May;98(5):836–841. doi: 10.1001/archopht.1980.01020030830004. [DOI] [PubMed] [Google Scholar]
  19. Remigio P. A., Klaum A. Extramedullary plasmacytoma of stomach. Cancer. 1971 Mar;27(3):562–568. doi: 10.1002/1097-0142(197103)27:3<562::aid-cncr2820270308>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  20. Rodman H. I., Font R. L. Orbital involvement in multiple myeloma. Review of the literature and report of three cases. Arch Ophthalmol. 1972 Jan;87(1):30–35. doi: 10.1001/archopht.1972.01000020032006. [DOI] [PubMed] [Google Scholar]
  21. Taylor C. R., Russell R., Chandor S. An immunohistologic study of multiple myeloma and related conditions, using an immunoperoxidase method. Am J Clin Pathol. 1978 Oct;70(4):612–622. doi: 10.1093/ajcp/70.4.612. [DOI] [PubMed] [Google Scholar]
  22. Todd I. D. Treatment of solitary plasmocytoma. Clin Radiol. 1965 Oct;16(4):395–399. doi: 10.1016/s0009-9260(65)80088-5. [DOI] [PubMed] [Google Scholar]
  23. Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore) 1976 May;55(3):217–238. doi: 10.1097/00005792-197605000-00002. [DOI] [PubMed] [Google Scholar]
  24. Woodruff R. K., Whittle J. M., Malpas J. S. Solitary plasmacytoma. I: Extramedullary soft tissue plasmacytoma. Cancer. 1979 Jun;43(6):2340–2343. doi: 10.1002/1097-0142(197906)43:6<2340::aid-cncr2820430625>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  25. Yee R. D., Savage D. D., Cogan D. G., Nienhuis A. W., Minna J. D. Plasma cell infiltration of the conjunctiva associated with pancytopenia, dermatitis, and polyclonal gammopathy. Am J Ophthalmol. 1976 Sep;82(3):486–491. doi: 10.1016/0002-9394(76)90499-2. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES