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. 1982 Dec;66(12):788–792. doi: 10.1136/bjo.66.12.788

Beta adrenergic receptors in pigmented ciliary processes.

G E Trope, B Clark
PMCID: PMC1039930  PMID: 6293532

Abstract

Beta adrenergic receptors from membrane fragments of pigmented sheep eyes were studied and characterised by ligand binding techniques after the removal of melanin. In a representative experiment the beta max (total number of beta receptors) was 394.9 fmol/mg protein. The receptor affinity (Ka) was 440 pM. The potency series of drugs to displace 125I-HYP from the receptors was timolol = (-) propranolol greater than (+) propranolol greater than salbutamol greater than practolol. beta 1 Receptors were not detected in the ciliary processes. beta 2 Receptors were the prominent adrenergic receptors present. The theory as to how beta blockers work in glaucoma, their site of action, and the potential role of beta 2 blockers for use in intraocular pressure control is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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