Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1983 Jan;67(1):32–36. doi: 10.1136/bjo.67.1.32

Effects of experimental hyperlipoproteinaemia on the retina and optic nerve in rhesus monkeys.

L Yanko, I C Michaelson, E Rosenmann, M Ivri, I Lutsky
PMCID: PMC1039941  PMID: 6848132

Abstract

Hyperlipoproteinaemia resulting from thyroid suppression and long-term ingestion of a high cholesterol diet caused prolonged lipaemia retinalis in 6 rhesus monkeys. No atherosclerotic deposits or other ophthalmoscopically visible changes of the retinal vasculature were detectable. In 2 animals histopathological examination revealed segmental atrophy and gliosis of the optic nerves bearing a resemblance to chronic ischaemic optic neuropathy. One monkey developed ophthalmoscopically visible temporal pallor of the optic discs. Emboli of fat laden cells in blood vessels of the brain in one of these 2 monkeys, and in a penicillated splenic artery in the other animal, were associated with signs of systemic embolic occlusion, suggesting a similar course in the development of optic nerve damage.

Full text

PDF
32

Images in this article

33Image
on p.33
34Image
on p.34
35Image
on p.35
35Image
on p.35

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBRINK M. J., MAN E. B., PETERS J. P. The relation of neutral fat to lactescence of serum. J Clin Invest. 1955 Feb;34(2):147–157. doi: 10.1172/JCI103069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson D. R., Davis E. B. Retina and optic nerve after posterior ciliary artery occlusion. An experimental study in squirrel monkeys. Arch Ophthalmol. 1974 Nov;92(5):422–426. doi: 10.1001/archopht.1974.01010010434013. [DOI] [PubMed] [Google Scholar]
  3. BARD L. A. ASTEROID HYALITIS: RELATIONSHIP TO DIABETES AND HYPERCHOLESTEROLEMIA. Am J Ophthalmol. 1964 Aug;58:239–242. [PubMed] [Google Scholar]
  4. COGAN D. G., KUWABARA T. Ocular changes in experimental hypercholesteremia. AMA Arch Ophthalmol. 1959 Feb;61(2):219–225. doi: 10.1001/archopht.1959.00940090221004. [DOI] [PubMed] [Google Scholar]
  5. COX G. E., TAYLOR C. B., COX L. G., COUNTS M. A. Atherosclerosis in rhesus monkeys. I. Hypercholesteremia induced by dietary fat and cholesterol. AMA Arch Pathol. 1958 Jul;66(1):32–52. [PubMed] [Google Scholar]
  6. DUNPHY E. B. Ocular conditions associated with idiopathic hyperlipemia. Am J Ophthalmol. 1950 Oct;33(10):1579–1586. doi: 10.1016/0002-9394(50)91220-7. [DOI] [PubMed] [Google Scholar]
  7. Hayreh S. S., Baines J. A. Occlusion of the posterior ciliary artery. 3. Effects on the optic nerve head. Br J Ophthalmol. 1972 Oct;56(10):754–764. doi: 10.1136/bjo.56.10.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. JANES R. G. CHANGES IN THE RABBIT'S EYE CAUSED BY CHOLESTEROL FEEDING. Am J Ophthalmol. 1964 Nov;58:819–828. [PubMed] [Google Scholar]
  9. Kramsch D. M., Hollander W. Occlusive atheroslcerotic disease of the coronary arteries in monkey (Macaca irus) induced by diet. Exp Mol Pathol. 1968 Aug;9(1):1–22. doi: 10.1016/0014-4800(68)90045-2. [DOI] [PubMed] [Google Scholar]
  10. Lieberman M. F., Shahi A., Green W. R. Embolic ischemic optic neuropathy. Am J Ophthalmol. 1978 Aug;86(2):206–210. doi: 10.1016/s0002-9394(14)76813-8. [DOI] [PubMed] [Google Scholar]
  11. SMITH J. L. Asteroid hyalitis: incidence of diabetes mellitus and hypercholesteremia. J Am Med Assoc. 1958 Oct 18;168(7):891–893. doi: 10.1001/jama.1958.63000070002010a. [DOI] [PubMed] [Google Scholar]
  12. Slatter D. H., Nelson A. W., Stringer J. M. Effects of experimental hyperlipoproteinemia on the canine eye. Exp Eye Res. 1979 Oct;29(4):437–447. doi: 10.1016/0014-4835(79)90061-7. [DOI] [PubMed] [Google Scholar]
  13. TAYLOR C. B., MANALO-ESTRELLA P., COX G. E. ATHEROSCLEROSIS IN RHESUS MONKEYS. V. MARKED DIET-INDUCED HYPERCHOLESTEREMIA WITH XANTHOMATOSIS AND SEVERE ATHEROSCLEROSIS. Arch Pathol. 1963 Sep;76:239–249. [PubMed] [Google Scholar]
  14. Vinger P. F., Sachs B. A. Ocular manifestations of hyperlipoproteinemia. Am J Ophthalmol. 1970 Oct;70(4):563–573. doi: 10.1016/0002-9394(70)90890-1. [DOI] [PubMed] [Google Scholar]
  15. Younger R. K., Scott H. W., Jr, Butts W. H., Stephenson S. E., Jr Rapid production of experimental hypercholesterolemia and atherosclerosis in the rhesus monkey: comparison of five dietary regimens. J Surg Res. 1969 May;9(5):263–271. doi: 10.1016/0022-4804(69)90064-x. [DOI] [PubMed] [Google Scholar]
  16. Zimmerman L. E., De Venecia G., Hamasaki D. I. Pathology of the optic nerve in experimental acute glaucoma. Invest Ophthalmol. 1967 Apr;6(2):109–125. [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES