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. 1983 Mar;67(3):143–146. doi: 10.1136/bjo.67.3.143

beta-thromboglobulin and platelet factor 4 levels in retinal vein occlusion.

P M Dodson, J Westwick, G Marks, V V Kakkar, D J Galton
PMCID: PMC1039996  PMID: 6186271

Abstract

Fifty-six patients with retinal vein occlusion--35 with central and 21 with branch vein occlusion--were investigated for comparison with an age and sex matched control group. Mean levels of beta-thromboglobulin and platelet factor 4 were significantly higher (p less than 0.001) in both the group with central and the group with branch retinal vein occlusion than in the control group. A significant increase of beta-thromboglobulin (p less than 0.001) was also found in the retinal vein occlusion group in those patients who were not hyperlipidaemic or diabetic (n = 39). Weak correlations were found between levels of lipoprotein cholesterol and plasma beta-thromboglobulin. Increased platelet aggregation may contribute to the aetiology of retinal vein occlusion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Betteridge D. J., Zahavi J., Jones N. A., Shine B., Kakkar V. V., Galton D. J. Platelet function in diabetes mellitus in relationship to complications, glycosylated haemoglobin and serum lipoproteins. Eur J Clin Invest. 1981 Aug;11(4):273–277. doi: 10.1111/j.1365-2362.1981.tb02116.x. [DOI] [PubMed] [Google Scholar]
  2. Cramp D. G., Robertson G. The fluorometric assay of triglyceride by a semiautomated method. Anal Biochem. 1968 Oct 24;25(1):246–251. doi: 10.1016/0003-2697(68)90097-3. [DOI] [PubMed] [Google Scholar]
  3. Dawes J., Smith R. C., Pepper D. S. The release, distribution, and clearance of human beta-thromboglobulin and platelet factor 4. Thromb Res. 1978 May;12(5):851–861. doi: 10.1016/0049-3848(78)90279-7. [DOI] [PubMed] [Google Scholar]
  4. Dodson P. M., Galton D. J., Hamilton A. M., Blach R. K. Retinal vein occlusion and the prevalence of lipoprotein abnormalities. Br J Ophthalmol. 1982 Mar;66(3):161–164. doi: 10.1136/bjo.66.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. French J. E. Atherogenesis and thrombosis. Semin Hematol. 1971 Jan;8(1):84–94. [PubMed] [Google Scholar]
  6. KLIEN B. A., OLWIN J. H. A survey of the pathogenesis of retinal venous occlusion, emphasis upon choice of therapy and an analysis of the therapeutic results in fifty-three patients. AMA Arch Ophthalmol. 1956 Aug;56(2):207–247. [PubMed] [Google Scholar]
  7. KLIEN B. A. Occlusion of the central retinal vein; clinical importance of certain histopathologic observations. Am J Ophthalmol. 1953 Mar;36(3):316–324. doi: 10.1016/0002-9394(53)91373-7. [DOI] [PubMed] [Google Scholar]
  8. Ludlam C. A. Evidence for the platelet specificity of beta-thromboglobulin and studies on its plasma concentration in healthy individuals. Br J Haematol. 1979 Feb;41(2):271–278. doi: 10.1111/j.1365-2141.1979.tb05855.x. [DOI] [PubMed] [Google Scholar]
  9. Moore S., Pepper D. S., Cash J. D. The isolation and characterisation of a platelet-specific beta-globulin (beta-thromboglobulin) and the detection of antiurokinase and antiplasmin released from thrombin-aggregated washed human platelets. Biochim Biophys Acta. 1975 Feb 27;379(2):360–369. doi: 10.1016/0005-2795(75)90143-9. [DOI] [PubMed] [Google Scholar]
  10. Onongbu I. C., Lewis B. Lipoprotein fractionation by a precipitation method. A simple quantitative procedure. Clin Chim Acta. 1976 Sep 20;71(3):397–402. doi: 10.1016/0009-8981(76)90090-5. [DOI] [PubMed] [Google Scholar]
  11. Priluck I. A. Impending central retinal vein occlusion associated with increased platelet aggregability. Ann Ophthalmol. 1979 Jan;11(1):79–84. [PubMed] [Google Scholar]
  12. Ring C. P., Pearson T. C., Sanders M. D., Wetherley-Mein G. Viscosity and retinal vein thrombosis. Br J Ophthalmol. 1976 Jun;60(6):397–410. doi: 10.1136/bjo.60.6.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. White A. M., Heptinstall S. Contribution of platelets to thrombus formation. Br Med Bull. 1978 May;34(2):123–128. doi: 10.1093/oxfordjournals.bmb.a071481. [DOI] [PubMed] [Google Scholar]
  14. Zahavi J., Betteridge J. D., Jones N. A., Galton D. J., Kakkar V. V. Enhanced in vivo platelet release reaction and malondialdehyde formation in patients with hyperlipidemia. Am J Med. 1981 Jan;70(1):59–64. doi: 10.1016/0002-9343(81)90412-5. [DOI] [PubMed] [Google Scholar]

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