Abstract
Oral atenolol (25 mg twice daily and 50 mg and 100 mg once daily) and placebo were tested as additional therapy in a double-masked, randomised, cross-over study. Twenty-four patients (16 with chronic simple glaucoma and 6 with ocular hypertension) participated who had an intraocular pressure (IOP) higher than 21 mmHg. The mean fall of intraocular pressure varied between 28% and 36% and was observed 2 to 6 hours after administration. After 2 weeks of treatment there was still a small fall in intraocular pressure (13%) after 12 hours (for the 25 mg dose) and 24 hours (for the 50 mg and 100 mg dose), but this was not significant (p less than 0.5). There was a fall in blood pressure and reduced pulse rate which persisted for at least 30 hours. Some patients complained of tiredness during treatment periods. Oral atenolol may be useful additional therapy for glaucoma.
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Selected References
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- Bonomi I., Steindler P. Effect of pindolol on intraocular pressure. Br J Ophthalmol. 1975 Jun;59(6):301–303. doi: 10.1136/bjo.59.6.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brenkman R. F. Long-term hypotensive effect of atenolol 4% eyedrops. Br J Ophthalmol. 1978 May;62(5):287–291. doi: 10.1136/bjo.62.5.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Castleden C. M., Dathan J. R., George C. F. A comparison of once and twice daily atenolol in hypertension. Postgrad Med J. 1977 Nov;53(625):679–682. doi: 10.1136/pgmj.53.625.679. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ellis M. E., Sahay J. N., Chatterjee S. S., Cruickshank J. M., Ellis S. H. Cardioselectivity of atenolol in asthmatic patients. Eur J Clin Pharmacol. 1981;21(3):173–176. doi: 10.1007/BF00627916. [DOI] [PubMed] [Google Scholar]
- Mishima S. Ocular effects of beta-adrenergic agents. XII Jules Stein Lecture. Surv Ophthalmol. 1982 Nov-Dec;27(3):187–208. doi: 10.1016/0039-6257(82)90072-8. [DOI] [PubMed] [Google Scholar]
- Phillips C. I., Gore S. M., Macdonald M. J., Cullen P. M. Atenolol eye drops in glaucoma: a double-masked, controlled study. Br J Ophthalmol. 1977 May;61(5):349–353. doi: 10.1136/bjo.61.5.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wettrell K., Pandolfi M. Effect of topical atenolol on intraocular pressure. Br J Ophthalmol. 1977 May;61(5):334–338. doi: 10.1136/bjo.61.5.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zacharias F. J., Cowen K. J., Cuthbertson P. F., Johnson T. B., Prestt J., Thompson J., Vickers J., Simpson W. T., Tuson R. Atenolol in hypertension a study of long-term therapy. Postgrad Med J. 1977;53 (Suppl 3):102–110. [PubMed] [Google Scholar]
- Zimmerman T. J., Boger W. P., 3rd The beta-adrenergic blocking agents and the treatment of glaucoma. Surv Ophthalmol. 1979 May-Jun;23(6):347–362. doi: 10.1016/0039-6257(79)90228-5. [DOI] [PubMed] [Google Scholar]