Abstract
Twelve patients with granulomatous uveitis were followed up longitudinally for as long as 20 months after their initial visit, and multiple serum antibody titres to bovine retinal S-antigen were determined and compared with the clinical activity at the time of each sampling. In those patients who presented with highly active lesions which then resolved during the course of the study without recurrences (7 toxoplasmosis and 1 pars planitis) the antibody titres reached a peak approximately 2 months after the initial visit and declined thereafter. No correlation of serum anti-S titres with clinical activity or predictable pattern of titres could be found in those patients who had recurrences during the course of the study (3 granulomatous iridocyclitis and 1 ocular sarcoidosis).
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Selected References
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- Abrahams I. W., Gregerson D. S. Longitudinal study of serum antibody responses to retinal antigens in acute ocular toxoplasmosis. Am J Ophthalmol. 1982 Feb;93(2):224–231. doi: 10.1016/0002-9394(82)90418-4. [DOI] [PubMed] [Google Scholar]
- Dorey C., Faure J. P. Isolement et caractérisation partielle d'un antigène rtinien responsable de l'uvéo-rétinite autoimmune expérimentale. Ann Immunol (Paris) 1977 Jan-Mar;128(1-2):229–232. [PubMed] [Google Scholar]
- Drachman D. B., Adams R. N., Josifek L. F., Self S. G. Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis. N Engl J Med. 1982 Sep 23;307(13):769–775. doi: 10.1056/NEJM198209233071301. [DOI] [PubMed] [Google Scholar]
- Dumonde D. C., Kasp-Grochowska E., Graham E., Sanders M. D., Faure J. P., de Kozak Y., van Tuyen V. Anti-retinal autoimmunity and circulating immune complexes in patients with retinal vasculitis. Lancet. 1982 Oct 9;2(8302):787–792. doi: 10.1016/s0140-6736(82)92679-4. [DOI] [PubMed] [Google Scholar]
- Faure J. P., Dorey C., Van Tuyen V., de Kozak Y. Experimental autoimmune uveo-retinitis and specificity of retinal antigens. Mod Probl Ophthalmol. 1976;16:21–29. [PubMed] [Google Scholar]
- Gregerson D. S., Abrahams I. W., Puklin J. E. Serum antibody responses to bovine retinal S-antigen and rod outer segments in proliferative diabetic retinopathy before and after argon laser photocoagulation. Ophthalmology. 1982 Jul;89(7):767–771. doi: 10.1016/s0161-6420(82)34725-9. [DOI] [PubMed] [Google Scholar]
- Gregerson D. S., Abrahams I. W., Thirkill C. E. Serum antibody levels of uveitis patients to bovine retinal antigens. Invest Ophthalmol Vis Sci. 1981 Nov;21(5):669–680. [PubMed] [Google Scholar]
- Kalsow C. M., Wacker W. B. Use of immunofluorescent localization in the normal guinea pig eye to differentiate three autoantisera. Int Arch Allergy Appl Immunol. 1975;48(2):287–293. doi: 10.1159/000231314. [DOI] [PubMed] [Google Scholar]
- Meyers R. L., Pettit T. H. Pathogenesis of experimental allergic uveitis induced by retinal rod outer segments and pigment epithelium. J Immunol. 1975 Apr;114(4):1269–1274. [PubMed] [Google Scholar]
- Nussenblatt R. B., Gery I., Ballintine E. J., Wacker W. B. Cellular immune responsiveness of uveitis patients to retinal S-antigen. Am J Ophthalmol. 1980 Feb;89(2):173–179. doi: 10.1016/0002-9394(80)90108-7. [DOI] [PubMed] [Google Scholar]
- Roses A. D., Olanow C. W., McAdams M. W., Lane R. J. No direct correlation between serum antiacetylcholine receptor antibody levels and clinical state of individual patients with myasthenia gravis. Neurology. 1981 Feb;31(2):220–224. doi: 10.1212/wnl.31.2.220. [DOI] [PubMed] [Google Scholar]
- Salinas-Carmona M. C., Nussenblatt R. B., Gery I. Experimental autoimmune uveitis in the athymic nude rat. Eur J Immunol. 1982 Jun;12(6):480–484. doi: 10.1002/eji.1830120606. [DOI] [PubMed] [Google Scholar]
- Wacker W. B. Autoimmune uveitis (choroiditis) in the guinea pig sensitized with homologous uvea and its differentiation from that following sensitization with homologous retina. Int Arch Allergy Appl Immunol. 1972;43(1):39–52. doi: 10.1159/000230819. [DOI] [PubMed] [Google Scholar]
- Wacker W. B., Donoso L. A., Kalsow C. M., Yankeelov J. A., Jr, Organisciak D. T. Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina. J Immunol. 1977 Dec;119(6):1949–1958. [PubMed] [Google Scholar]
- de Kozak Y., Sainte-Laudy J., Benveniste J., Faure J. P. Evidence for immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis. Eur J Immunol. 1981 Aug;11(8):612–617. doi: 10.1002/eji.1830110805. [DOI] [PubMed] [Google Scholar]
- de Kozak Y., Youn W. S., Bogossian M., Faure J. P. Humoral and cellular immunity to retinal antigens in guinea pigs. Mod Probl Ophthalmol. 1976;16:51–58. [PubMed] [Google Scholar]
