Abstract
Children with homozygous sickle cell (SS) disease and with sickle cell-haemoglobin C (SC) disease, aged 6 1/2 to 8 1/2 years, were examined by fluorescein angiography/angioscopy to determine the presence of retinal nonperfusion. The haematological and clinical features of children with and without nonperfusion were compared. Retinal vessel closure was significantly correlated with low total haemoglobin, and high fetal haemoglobin, reticulocyte, and irreversibly sickled cell counts in SS disease, and with high reticulocyte count in SC disease. No relationships were apparent between vessel closure and other haematological indices or clinical events in either genotype.
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- Condon P. I., Serjeant G. R. Behaviour of untreated proliferative sickle retinopathy. Br J Ophthalmol. 1980 Jun;64(6):404–411. doi: 10.1136/bjo.64.6.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Condon P. I., Serjeant G. R. Ocular findings in hemoglobin SC disease in Jamaica. Am J Ophthalmol. 1972 Nov;74(5):921–931. doi: 10.1016/0002-9394(72)91213-5. [DOI] [PubMed] [Google Scholar]
- Condon P. I., Serjeant G. R. Ocular findings in homozygous sickle cell anemia in Jamaica. Am J Ophthalmol. 1972 Apr;73(4):533–543. doi: 10.1016/0002-9394(72)90005-0. [DOI] [PubMed] [Google Scholar]
- Galinos S. O., Asdourian G. K., Woolf M. B., Stevens T. S., Lee C. B., Goldberg M. F., Chow J. C., Busse B. J. Spontaneous remodeling of the peripheral retinal vasculature in sickling disorders. Am J Ophthalmol. 1975 May;79(5):853–870. doi: 10.1016/0002-9394(75)90747-3. [DOI] [PubMed] [Google Scholar]
- Hayes R. J., Condon P. I., Serjeant G. R. Haematological factors associated with proliferative retinopathy in homozygous sickle cell disease. Br J Ophthalmol. 1981 Jan;65(1):29–35. doi: 10.1136/bjo.65.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hayes R. J., Condon P. I., Serjeant G. R. Haematological factors associated with proliferative retinopathy in sickle cell-haemoglobin C disease. Br J Ophthalmol. 1981 Oct;65(10):712–717. doi: 10.1136/bjo.65.10.712. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Serjeant G. R., Serjeant B. E., Milner P. F. The irreversibly sickled cell; a determinant of haemolysis in sickle cell anaemia. Br J Haematol. 1969 Dec;17(6):527–533. doi: 10.1111/j.1365-2141.1969.tb01403.x. [DOI] [PubMed] [Google Scholar]
- Talbot J. F., Bird A. C., Serjeant G. R., Hayes R. J. Sickle cell retinopathy in young children in Jamaica. Br J Ophthalmol. 1982 Mar;66(3):149–154. doi: 10.1136/bjo.66.3.149. [DOI] [PMC free article] [PubMed] [Google Scholar]