Abstract
The immediate effects of topical salbutamol, a beta 2 adrenergic agonist, on the aqueous humour dynamics of 22 normal subjects was studied by fluorophotometry and tonography. Significant lowering of intraocular pressure was accompanied by a significant increase in both aqueous flow rate and tonographic facility of outflow. Uveoscleral outflow was calculated and found to be significantly increased by salbutamol. This appeared to be the predominant acute pressure lowering effect of beta receptor stimulation in the normal human eye.
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Selected References
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- Bill A. Effects of norepinephrine, isoproterenol and sympathetic stimulation on aqueous humour dynamics in vervet monkeys. Exp Eye Res. 1970 Jul;10(1):31–46. doi: 10.1016/s0014-4835(70)80006-9. [DOI] [PubMed] [Google Scholar]
- Brubaker R. F., Coakes R. L. Use of a xenon flash tube as the excitation source in a new slit-lamp fluorophotometer. Am J Ophthalmol. 1978 Oct;86(4):474–484. doi: 10.1016/0002-9394(78)90292-1. [DOI] [PubMed] [Google Scholar]
- Coakes R. L., Brubaker R. F. Method of measuring aqueous humor flow and corneal endothelial permeability using a fluorophotometry nomogram. Invest Ophthalmol Vis Sci. 1979 Mar;18(3):288–302. [PubMed] [Google Scholar]
- Coakes R. L., Brubaker R. F. The mechanism of timolol in lowering intraocular pressure. In the normal eye. Arch Ophthalmol. 1978 Nov;96(11):2045–2048. doi: 10.1001/archopht.1978.03910060433007. [DOI] [PubMed] [Google Scholar]
- Langham M. E., Diggs E. Beta-adrenergic responses in the eyes of rabbits, primates, and man. Exp Eye Res. 1974 Sep;19(3):281–295. doi: 10.1016/0014-4835(74)90147-x. [DOI] [PubMed] [Google Scholar]
- Nathanson J. A. Human ciliary process adrenergic receptor: pharmacological characterization. Invest Ophthalmol Vis Sci. 1981 Dec;21(6):798–804. [PubMed] [Google Scholar]
- Paterson G. D., Paterson G. Drug therapy of glaucoma. Br J Ophthalmol. 1972 Mar;56(3):288–294. doi: 10.1136/bjo.56.3.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sonntag J. R., Brindley G. O., Shields M. B. Effect of timolol therapy on outflow facility. Invest Ophthalmol Vis Sci. 1978 Mar;17(3):293–296. [PubMed] [Google Scholar]
- Townsend D. J., Brubaker R. F. Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry. Invest Ophthalmol Vis Sci. 1980 Mar;19(3):256–266. [PubMed] [Google Scholar]
- Yablonski M. E., Zimmerman T. J., Waltman S. R., Becker B. A fluorophotometric study of the effect of topical timolol on aqueous humor dynamics. Exp Eye Res. 1978 Aug;27(2):135–142. doi: 10.1016/0014-4835(78)90083-0. [DOI] [PubMed] [Google Scholar]
- Zimmerman T. J., Harbin R., Pett M., Kaufman H. E. Timolol and facility of outflow. Invest Ophthalmol Vis Sci. 1977 Jul;16(7):623–624. [PubMed] [Google Scholar]