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. 2023 Jul 13;26(8):107376. doi: 10.1016/j.isci.2023.107376

Figure 1.

Figure 1

Expression of STING in TAMs correlates with liver metastasis of colorectal cancer

(A) Representative IHC stained images of STING protein in primary liver metastatic and paracancerous tissue of human colorectal cancers.

(B) Visualization of t-SNE in macrophage clusters based on single-cell transcriptomes.

(C) Expression levels of STING in different macrophage subtypes.

(D) Analysis of STING expression in primary CRC with metastasis tissues in CRC microarray profile.

(E) Boxplots representing the distribution of M1 (CCL5+) or M2 (CCL18+) cells in primary and metastatic tumors.

(F) Correlation between the mRNA expression of STING and M1/M2 macrophage obtained from Tumor Immune Estimation Resource (TIMER2.0, http://timer.cistrome.org/).