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. 1985 Feb;69(2):77–85. doi: 10.1136/bjo.69.2.77

Damage to the corneal endothelium during Nd/YAG photodisruption.

M G Kerr Muir, E S Sherrard
PMCID: PMC1040529  PMID: 3838136

Abstract

Damage to the human corneal endothelium, as seen by specular microscopy, associated with short pulsed neodymium: yttrium-aluminium-garnet (Nd/YAG) laser iridotomy and capsulotomy, is described. A specular and scanning electron microscopical study of fresh in vitro rabbit eyes submitted to Nd/YAG iridotomy was performed to investigate the nature of the endothelial damage. The majority of lesions showed irreversible changes ranging from individual cell destruction to disruption of large areas of the endothelium, while cells adjacent to these lesions had changes of an apparently reversible nature. It was possible to correlate accurately these scanning electron microscopic changes with the appearances seen with the clinical specular microscope. The extent of such damage appears to be related to the quantity of power delivered, its delivery mode, the number of laser bursts, and the target tissue/endothelium distance. The possible causes for such damage are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aron-Rosa D., Aron J. J., Griesemann M., Thyzel R. Use of the neodymium-YAG laser to open the posterior capsule after lens implant surgery: a preliminary report. J Am Intraocul Implant Soc. 1980 Oct;6(4):352–354. doi: 10.1016/s0146-2776(80)80036-x. [DOI] [PubMed] [Google Scholar]
  2. Aron-Rosa D. Use of a pulsed neodymium-Yag laser for anterior capsulotomy before extracapsular cataract extraction. J Am Intraocul Implant Soc. 1981 Fall;7(4):332–333. doi: 10.1016/s0146-2776(81)80029-8. [DOI] [PubMed] [Google Scholar]
  3. Bigar F., Witmer R. Corneal endothelial changes in primary acute angle-closure glaucoma. Ophthalmology. 1982 Jun;89(6):596–599. doi: 10.1016/s0161-6420(82)34744-2. [DOI] [PubMed] [Google Scholar]
  4. Bonney C. H., Gaasterland D. E. Low-energy, Q-switched ruby laser iridotomies in Macaca mulatta. Invest Ophthalmol Vis Sci. 1979 Mar;18(3):278–287. [PubMed] [Google Scholar]
  5. Fankhauser F., Lörtscher H., van der Zypen E. Clinical studies on high and low power laser radiation upon some structures of the anterior and posterior segments of the eye. Experiences in the treatment of some pathological conditions of the anterior and posterior segments of the human eye by means of a Nd:YAG laser, driven at various power levels. Int Ophthalmol. 1982 May;5(1):15–32. doi: 10.1007/BF00129992. [DOI] [PubMed] [Google Scholar]
  6. Fankhauser F., Roussel P., Steffen J., Van der Zypen E., Chrenkova A. Clinical studies on the efficiency of high power laser radiation upon some structures of the anterior segment of the eye. First experiences of the treatment of some pathological conditions of the anterior segment of the human eye by means of a Q-switched laser system. Int Ophthalmol. 1981 May;3(3):129–139. doi: 10.1007/BF00130696. [DOI] [PubMed] [Google Scholar]
  7. Goldman A. I., Ham W. T., Jr, Mueller H. A. Mechanisms of retinal damage resulting from the exposure of rhesus monkeys to ultrashort laser pulses. Exp Eye Res. 1975 Nov;21(5):457–469. doi: 10.1016/0014-4835(75)90127-x. [DOI] [PubMed] [Google Scholar]
  8. Jampol L. M., Goldberg M. F., Jednock N. Retinal damage from a Q-switched YAG laser. Am J Ophthalmol. 1983 Sep;96(3):326–329. doi: 10.1016/s0002-9394(14)77823-7. [DOI] [PubMed] [Google Scholar]
  9. Mainster M. A., Sliney D. H., Belcher C. D., 3rd, Buzney S. M. Laser photodisruptors. Damage mechanisms, instrument design and safety. Ophthalmology. 1983 Aug;90(8):973–991. [PubMed] [Google Scholar]
  10. Mainster M. A., White T. J., Allen R. G. Spectral dependence of retinal damage produced by intense light sources. J Opt Soc Am. 1970 Jun;60(6):848–855. doi: 10.1364/josa.60.000848. [DOI] [PubMed] [Google Scholar]
  11. Mainster M. A., White T. J., Tips J. H., Wilson P. W. Retinal-temperature increases produced by intense light sources. J Opt Soc Am. 1970 Feb;60(2):264–270. doi: 10.1364/josa.60.000264. [DOI] [PubMed] [Google Scholar]
  12. Marshall J. Thermal and mechanical mechanisms in laser damage to the retina. Invest Ophthalmol. 1970 Feb;9(2):97–115. [PubMed] [Google Scholar]
  13. Mishima S. Clinical investigations on the corneal endothelium. Ophthalmology. 1982 Jun;89(6):525–530. doi: 10.1016/s0161-6420(82)34755-7. [DOI] [PubMed] [Google Scholar]
  14. Puliafito C. A., Steinert R. F. Laser surgery of the lens. Experimental studies. Ophthalmology. 1983 Aug;90(8):1007–1012. doi: 10.1016/s0161-6420(83)80028-1. [DOI] [PubMed] [Google Scholar]
  15. Sherrard E. S., Buckley R. J. Contact clinical specular microscopy of the corneal endothelium: optical modifications to the applanating objective cone. Invest Ophthalmol Vis Sci. 1981 Jun;20(6):816–820. [PubMed] [Google Scholar]

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