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. 1985 Mar;69(3):219–227. doi: 10.1136/bjo.69.3.219

Possible cataractogenic effect of radionuclides deposited within the eye from the blood stream.

T P Griffith, A Pirie, J Vaughan
PMCID: PMC1040567  PMID: 3978069

Abstract

The clinical and histological examination of a cataract in a man of 47 is described together with a review of the deposition of radionuclides in the eye. It is suggested that the cataract was possibly due, at least in part, to irradiation of the sensitive cells in the germinative zone of the lens epithelium by alpha particles deposited in the pigmented tissues of the eye from the 239Pu circulating in the blood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams E. E., Brues A. M., Anast G. A. Survey of ocular cataracts in radium dial workers. Health Phys. 1983;44 (Suppl 1):73–79. doi: 10.1097/00004032-198306001-00005. [DOI] [PubMed] [Google Scholar]
  2. Baverstock K. F., Papworth D., Vennart J. Risks of radiation at low dose rates. Lancet. 1981 Feb 21;1(8217):430–433. doi: 10.1016/s0140-6736(81)91804-3. [DOI] [PubMed] [Google Scholar]
  3. CAIRD F. I., HUTCHINSON M., PIRIE A. CATARACT EXTRACTION IN AN ENGLISH POPULATION. Br J Prev Soc Med. 1965 Apr;19:80–84. doi: 10.1136/jech.19.2.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COGAN D. G., DONALDSON D. D. Experimental radiation cataracts. I. Cataracts in the rabbit following single x-ray exposure. AMA Arch Ophthalmol. 1951 May;45(5):508–522. [PubMed] [Google Scholar]
  5. COGAN D. G., DONALDSON D. D., REESE A. B. Clinical and pathological characteristics of radiation cataract. AMA Arch Ophthalmol. 1952 Jan;47(1):55–70. doi: 10.1001/archopht.1952.01700030058006. [DOI] [PubMed] [Google Scholar]
  6. Dodo T. Review of thirty years study of Hiroshima and Nagasaki atomic bomb survivors. II. Biological effects. H. Cataracts. J Radiat Res. 1975 Sep;16 (Suppl):132–137. doi: 10.1269/jrr.16.supplement_132. [DOI] [PubMed] [Google Scholar]
  7. Hayes B. P., Fisher R. F. Influence of a prolonged period of low-dosage x-rays on the optic and ultrastructural appearances of cataract of the human lens. Br J Ophthalmol. 1979 Jul;63(7):457–464. doi: 10.1136/bjo.63.7.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MOLE R. H., PIRIE A., VAUGHAN J. M. Differential distribution of radioactive strontium and yttrium in the tissues of the rabbit's eye. Nature. 1959 Mar 21;183(4664):802–807. doi: 10.1038/183802a0. [DOI] [PubMed] [Google Scholar]
  9. Mole R. H. The radiobiological significance of the studies with 224Ra and thorotrast. Health Phys. 1978 Jul;35(1):167–174. doi: 10.1097/00004032-197807000-00016. [DOI] [PubMed] [Google Scholar]
  10. Otake M., Schull W. J. The relationship of gamma and neutron radiation to posterior lenticular opacities among atomic bomb survivors in Hiroshima and Nagasaki. Radiat Res. 1982 Dec;92(3):574–595. [PubMed] [Google Scholar]
  11. SOWDEN E., PIRIE A. Barium and strontium concentrations in eye tissue. Biochem J. 1958 Dec;70(4):716–717. doi: 10.1042/bj0700716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Spiess H., Gerspach A. Soft-tissue effects following 224Ra injections into humans. Health Phys. 1978 Jul;35(1):61–81. doi: 10.1097/00004032-197807000-00006. [DOI] [PubMed] [Google Scholar]
  13. VON SALLMANN L. Experimental studies on early lens changes after roentgen irradiation. III. Effect of x-radiation on mitotic activity and nuclear fragmentation of lens epithelium in normal and cysteine-treated rabbits. AMA Arch Ophthalmol. 1952 Mar;47(3):305–320. [PubMed] [Google Scholar]
  14. VON SALLMANN L., TOBIAS C. A., ANGER H. O., WELCH C., KIMURA S. F., MUNOZ C. M., DRUNGIS A. Effects of high-energy particles, X-rays, and aging on lens epithelium. AMA Arch Ophthalmol. 1955 Oct;54(4):489–514. doi: 10.1001/archopht.1955.00930020495003. [DOI] [PubMed] [Google Scholar]
  15. Wick R. R., Gössner W. Follow-up study of late effects in 224Ra treated ankylosing spondylitis patients. Health Phys. 1983;44 (Suppl 1):187–195. doi: 10.1097/00004032-198306001-00015. [DOI] [PubMed] [Google Scholar]
  16. Wick R. R., Müller W. A., Linzner U. Distribution studies in mice of 224Ra in colloidal ("Peteosthor") and ionic preparations as used in human therapy. Health Phys. 1983;44 (Suppl 1):580–583. [PubMed] [Google Scholar]

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