Skip to main content
PMC home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1985 Apr;69(4):275–279. doi: 10.1136/bjo.69.4.275

Prostaglandin levels in human vitreous.

M A Thomas, G E O'Grady, S L Swartz
PMCID: PMC1040582  PMID: 3857940

Abstract

Vitreous samples were obtained from 41 eyes undergoing vitrectomy, and radioimmunoassays were performed to measure concentrations of the prostaglandins PGE2, PGF2 alpha, prostacyclin, and thromboxane. Presumably physiological levels (approximately 100 picograms/ml) were found in vitreous from eyes undergoing cataract extraction. Eyes with vitreous haemorrhage, retinal detachment, or cystoid macular oedema had similarly low levels. Vitreous prostaglandins were mildly elevated in trauma and endophthalmitis and markedly elevated in aphakic bullous keratopathy. The role prostaglandins may play in cystoid macular oedema is reviewed.

Full text

PDF
275

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Eakins K. E. Prostaglandin and non-prostaglandin mediated breeakdown of the blood-aqueous barrier. Exp Eye Res. 1977;25 (Suppl):483–498. doi: 10.1016/s0014-4835(77)80043-2. [DOI] [PubMed] [Google Scholar]
  2. Federman J. L., Annesley W. H., Jr, Sarin L. K., Remer P. Vitrectomy and cystoid macular edema. Ophthalmology. 1980 Jul;87(7):622–628. doi: 10.1016/s0161-6420(80)35191-9. [DOI] [PubMed] [Google Scholar]
  3. Floman N., Zor U. Mechanism of steroid action in ocular inflammation: Inhibition of prostaglandin production. Invest Ophthalmol Vis Sci. 1977 Jan;16(1):69–73. [PubMed] [Google Scholar]
  4. Fung W. E. Anterior vitrectomy for chronic aphakic cystoid macular edema. Ophthalmology. 1980 Mar;87(3):189–193. doi: 10.1016/s0161-6420(80)35253-6. [DOI] [PubMed] [Google Scholar]
  5. Fung W. E. Surgical therapy for chronic aphakic cystoid macular edema. Ophthalmology. 1982 Aug;89(8):898–901. doi: 10.1016/s0161-6420(82)34709-0. [DOI] [PubMed] [Google Scholar]
  6. Gass J. D., Norton E. W. Follow-up study of cystoid macular edema following cataract extraction. Trans Am Acad Ophthalmol Otolaryngol. 1969 Jul-Aug;73(4):665–682. [PubMed] [Google Scholar]
  7. Iliff C. E. Treatment of the vitreous-tug syndrome. Am J Ophthalmol. 1966 Nov;62(5):856–859. doi: 10.1016/0002-9394(66)91910-6. [DOI] [PubMed] [Google Scholar]
  8. Izawa Y., Masuda K. [Estimation of prostaglandins by radioimmunoassay in rabbit aqueous humor after paracentesis (author's transl)]. Nippon Ganka Gakkai Zasshi. 1976 Aug 10;80(8):448–451. [PubMed] [Google Scholar]
  9. Jampol L. M. Pharmacologic therapy of aphakic cystoid macular edema. A review. Ophthalmology. 1982 Aug;89(8):891–897. doi: 10.1016/s0161-6420(82)34699-0. [DOI] [PubMed] [Google Scholar]
  10. Katz I. M. Indomethacin. Ophthalmology. 1981 May;88(5):455–458. doi: 10.1016/s0161-6420(81)35004-0. [DOI] [PubMed] [Google Scholar]
  11. Klein R. M., Katzin H. M., Yannuzzi L. A. The effect of indomethacin pretreatment on aphakic cystoid macular edema. Am J Ophthalmol. 1979 Apr;87(4):487–489. doi: 10.1016/0002-9394(79)90235-6. [DOI] [PubMed] [Google Scholar]
  12. Levine L. Levels of 13,14-dihydro-15-keto-PGE2 in some biological fluids as measured by radioimmunoassay. Prostaglandins. 1977;14(6):1125–1139. doi: 10.1016/0090-6980(77)90290-8. [DOI] [PubMed] [Google Scholar]
  13. Miyake K. Prevention of cystoid macular edema after lens extraction by topical indomethacin (I). A preliminary report. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Aug 8;203(2):81–88. doi: 10.1007/BF00413399. [DOI] [PubMed] [Google Scholar]
  14. Miyake K., Sakamura S., Miura H. Long-term follow-up study on prevention of aphakic cystoid macular oedema by topical indomethacin. Br J Ophthalmol. 1980 May;64(5):324–328. doi: 10.1136/bjo.64.5.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rao G. H., Burris S. M., Gerrard J. M., White J. G. Inhibition of prostaglandin (PG) synthesis in sheep vesicular gland microsomes (SVGM) by nitroblue tetrazolium (NBT) and vitamin E (VE). Prostaglandins Med. 1979 Feb;2(2):111–121. doi: 10.1016/0161-4630(79)90046-6. [DOI] [PubMed] [Google Scholar]
  16. Rao G. H., Burris S. M., Gerrard J. M., White J. G. Inhibition of prostaglandin (PG) synthesis in sheep vesicular gland microsomes (SVGM) by nitroblue tetrazolium (NBT) and vitamin E (VE). Prostaglandins Med. 1979 Feb;2(2):111–121. doi: 10.1016/0161-4630(79)90046-6. [DOI] [PubMed] [Google Scholar]
  17. Sholiton D. B., Reinhart W. J., Frank K. E. Indomethacin as a means of preventing cystoid macular edema following intracapsular cataract extraction. J Am Intraocul Implant Soc. 1979 Apr;5(2):137–140. doi: 10.1016/s0146-2776(79)80053-1. [DOI] [PubMed] [Google Scholar]
  18. Swartz S. L., Williams G. H., Hollenberg N. K., Levine L., Dluhy R. G., Moore T. J. Captopril-induced changes in prostaglandin production: relationship to vascular responses in normal man. J Clin Invest. 1980 Jun;65(6):1257–1264. doi: 10.1172/JCI109788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Yannuzzi L. A., Klein R. M., Wallyn R. H., Cohen N., Katiz I. Ineffectiveness of indomethacin in the treatment of chronic cystoid macular edema. Am J Ophthalmol. 1977 Oct;84(4):517–519. doi: 10.1016/0002-9394(77)90444-5. [DOI] [PubMed] [Google Scholar]
  20. Yannuzzi L. A., Landau A. N., Turtz A. I. Incidence of aphakic cystoid macular edema with the use of topical indomethacin. Ophthalmology. 1981 Sep;88(9):947–954. doi: 10.1016/s0161-6420(81)80010-3. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES