Abstract
Anterior segment fluorescein angiography in scleral disease reveals highly characteristic changes in the vasculature of the anterior segment associated with necrotising scleritis. The vaso-obliterative changes discovered in this investigation have been correlated with the histopathology in a patient who had to have tissue replaced. Light and electron microscopy of scleral tissue excised from sites of vascular closure detected by fluorescein angiography peripheral to the scleral defect revealed pathological changes in the absence of inflammatory cell infiltration. These changes included vascular stasis, partial vaso-obliteration, and fibroblastic transformation of scleral fibrocytes in association with intra- and extracellular degradation of the collagenous component of the matrix.
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- François J. Ocular manifestations in collagenoses (with colour plates I and II). Adv Ophthalmol. 1970;23:1–54. [PubMed] [Google Scholar]
- Harris E. D., Jr, Glauert A. M., Murley A. H. Intracellular collagen fibers at the pannus-cartilage junction in rheumatoid arthritis. Arthritis Rheum. 1977 Mar;20(2):657–665. doi: 10.1002/art.1780200204. [DOI] [PubMed] [Google Scholar]
- Padykula H. A. Cellular mechanisms involved in cyclic stroma renewal of the uterus. III. Cells of the immune response. Anat Rec. 1976 Jan;184(1):49–71. doi: 10.1002/ar.1091840105. [DOI] [PubMed] [Google Scholar]
- Sevel D. Necrogranulomatous scleritis. Clinical and histologic features. Am J Ophthalmol. 1967 Dec;64(6):1125–1134. [PubMed] [Google Scholar]
- Young R. D., Watson P. G. Microscopical studies of necrotising scleritis. I. Cellular aspects. Br J Ophthalmol. 1984 Nov;68(11):770–780. doi: 10.1136/bjo.68.11.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Young R. D., Watson P. G. Microscopical studies of necrotising scleritis. II. Collagen degradation in the scleral stroma. Br J Ophthalmol. 1984 Nov;68(11):781–789. doi: 10.1136/bjo.68.11.781. [DOI] [PMC free article] [PubMed] [Google Scholar]