Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1986 Aug;70(8):561–569. doi: 10.1136/bjo.70.8.561

Experimental posterior perforating ocular injury: a controlled study of the gross effects of localised gamma irradiation.

U Chakravarthy, C J Maguire, D B Archer
PMCID: PMC1040772  PMID: 3741819

Abstract

A pilot study on the effect of localised irradiation applied to the site of a standard perforating injury in the rabbit eye, showed that gamma rays limited the formation of post-traumatic vitreoretinal membranes. A controlled study was therefore undertaken to confirm this observation. Twenty-four pairs of rabbits underwent a standard perforating injury in the right eye. One rabbit of each pair received a radioactive ophthalmic Cobalt applicator and the other a dummy applicator. Nineteen of 24 non-irradiated eyes developed vitreoretinal membranes, with associated traction retinal detachment. Only four of 24 irradiated eyes developed traction retinal detachment.

Full text

PDF
561

Images in this article

564Image
on p.564
566Image
on p.566
567Image
on p.567
568Image
on p.568

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arlett C. F., Harcourt S. A. Survey of radiosensitivity in a variety of human cell strains. Cancer Res. 1980 Mar;40(3):926–932. [PubMed] [Google Scholar]
  2. Bedford M. A., Bedotto C., Macfaul P. A. Retinoblastoma. A study of 139 cases. Br J Ophthalmol. 1971 Jan;55(1):19–27. doi: 10.1136/bjo.55.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Belkin M., Avni I., Kessler E., Hercberg A., Spierer A., Treister G. X-irradiation in the prevention of experimental post-traumatic vitreous proliferation. Curr Eye Res. 1982;2(11):753–756. doi: 10.3109/02713688209020007. [DOI] [PubMed] [Google Scholar]
  4. Blumenkranz M., Hernandez E., Ophir A., Norton E. W. 5-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. Ophthalmology. 1984 Feb;91(2):122–130. doi: 10.1016/s0161-6420(84)34318-4. [DOI] [PubMed] [Google Scholar]
  5. Casebow M. P. The calculation and measurement of exposure distributions from 60 Co ophthalmic applicators. Br J Radiol. 1971 Aug;44(524):618–624. doi: 10.1259/0007-1285-44-524-618. [DOI] [PubMed] [Google Scholar]
  6. Cleary P. E., Minckler D. S., Ryan S. J. Ultrastructure of traction retinal detachment in rhesus monkey eyes after a posterior penetrating ocular injury. Am J Ophthalmol. 1980 Dec;90(6):829–845. doi: 10.1016/s0002-9394(14)75198-0. [DOI] [PubMed] [Google Scholar]
  7. Cleary P. E., Ryan S. J. Experimental posterior penetrating eye injury in the rabbit. II. Histology of wound, vitreous, and retina. Br J Ophthalmol. 1979 May;63(5):312–321. doi: 10.1136/bjo.63.5.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cleary P. E., Ryan S. J. Posterior perforating eye injury. Experimental animal model. Trans Ophthalmol Soc U K. 1978 Apr;98(1):34–37. [PubMed] [Google Scholar]
  9. Cox R., Masson W. K. Radiosensitivity in cultured human fibroblasts. Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Nov;38(5):575–576. doi: 10.1080/09553008014551391. [DOI] [PubMed] [Google Scholar]
  10. Cruess A. F., Augsburger J. J., Shields J. A., Donoso L. A., Amsel J. Visual results following cobalt plaque radiotherapy for posterior uveal melanomas. Ophthalmology. 1984 Feb;91(2):131–136. doi: 10.1016/s0161-6420(84)34317-2. [DOI] [PubMed] [Google Scholar]
  11. De Juan E., Jr, Sternberg P., Jr, Michels R. G. Penetrating ocular injuries. Types of injuries and visual results. Ophthalmology. 1983 Nov;90(11):1318–1322. doi: 10.1016/s0161-6420(83)34387-6. [DOI] [PubMed] [Google Scholar]
  12. Eagling E. M. Perforating injuries involving the posterior segment. Trans Ophthalmol Soc U K. 1975 Jul;95(2):335–339. [PubMed] [Google Scholar]
  13. Faulborn J., Topping T. M. Proliferations in the vitreous cavity after perforating injuries. A histopathological study. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Feb 22;205(3):157–166. doi: 10.1007/BF00414395. [DOI] [PubMed] [Google Scholar]
  14. Grierson I., Rahi A. H. Structural basis of contraction in vitreal fibrous membranes. Br J Ophthalmol. 1981 Nov;65(11):737–749. doi: 10.1136/bjo.65.11.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hiscott P. S., Grierson I., Hitchins C. A., Rahi A. H., McLeod D. Epiretinal membranes in vitro. Trans Ophthalmol Soc U K. 1983;103(Pt 1):89–102. [PubMed] [Google Scholar]
  16. Kampik A., Kenyon K. R., Michels R. G., Green W. R., de la Cruz Z. C. Epiretinal and vitreous membranes. Comparative study of 56 cases. Arch Ophthalmol. 1981 Aug;99(8):1445–1454. doi: 10.1001/archopht.1981.03930020319025. [DOI] [PubMed] [Google Scholar]
  17. Machemer R. A new concept for vitreous surgery. 2. Surgical technique and complications. Am J Ophthalmol. 1972 Dec;74(6):1022–1033. doi: 10.1016/0002-9394(72)90719-2. [DOI] [PubMed] [Google Scholar]
  18. Machemer R. Pathogenesis and classification of massive periretinal proliferation. Br J Ophthalmol. 1978 Nov;62(11):737–747. doi: 10.1136/bjo.62.11.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Moorhead L. C. Effects of beta-aminopropionitrile after posterior penetrating injury in the rabbit. Am J Ophthalmol. 1983 Jan;95(1):97–109. doi: 10.1016/0002-9394(83)90337-9. [DOI] [PubMed] [Google Scholar]
  20. Newsome D. A., Rodrigues M. M., Machemer R. Human massive periretinal proliferation. In vitro characteristics of cellular components. Arch Ophthalmol. 1981 May;99(5):873–880. doi: 10.1001/archopht.1981.03930010873017. [DOI] [PubMed] [Google Scholar]
  21. Peczon B. D., Wolfe J. K., Gipson I. K., Hirose T., Buzney S. M., Schepens C. L. Characterization of membranes removed during open-sky vitrectomy. Invest Ophthalmol Vis Sci. 1983 Oct;24(10):1382–1389. [PubMed] [Google Scholar]
  22. Ryan S. J., Allen A. W. Pars plana vitrectomy in ocular trauma. Am J Ophthalmol. 1979 Sep;88(3 Pt 1):483–491. doi: 10.1016/0002-9394(79)90651-2. [DOI] [PubMed] [Google Scholar]
  23. STALLARD H. B. The conservative treatment of retinoblastoma. Trans Ophthalmol Soc U K. 1962;82:473–534. [PubMed] [Google Scholar]
  24. Stern W. H., Fisher S. K., Anderson D. H., O'Donnell J. J., Erickson P. A., Lewis G. P., Guerin C. J., Borgula G. A., McDermott M. A. Epiretinal membrane formation after vitrectomy. Am J Ophthalmol. 1982 Jun;93(6):757–772. doi: 10.1016/0002-9394(82)90472-x. [DOI] [PubMed] [Google Scholar]
  25. Stern W. H., Guerin C. J., Erickson P. A., Lewis G. P., Anderson D. H., Fisher S. K. Ocular toxicity of fluorouracil after vitrectomy. Am J Ophthalmol. 1983 Jul;96(1):43–51. doi: 10.1016/0002-9394(83)90453-1. [DOI] [PubMed] [Google Scholar]
  26. Tano Y., Sugita G., Abrams G., Machemer R. Inhibition of intraocular proliferations with intravitreal corticosteroids. Am J Ophthalmol. 1980 Jan;89(1):131–136. doi: 10.1016/0002-9394(80)90239-1. [DOI] [PubMed] [Google Scholar]
  27. Topping T. M., Abrams G. W., Machemer R. Experimental double-perforating injury of the posterior segment in rabbit eyes: the natural history of intraocular proliferation. Arch Ophthalmol. 1979 Apr;97(4):735–742. doi: 10.1001/archopht.1979.01020010387024. [DOI] [PubMed] [Google Scholar]
  28. Ussmann J. H., Lazarides E., Ryan S. J. Traction retinal detachment. A cell-mediated event. Arch Ophthalmol. 1981 May;99(5):869–872. doi: 10.1001/archopht.1981.03930010869016. [DOI] [PubMed] [Google Scholar]
  29. Weiss J. F., Belkin M. The effect of penicillamine on posttraumatic vitreous proliferation. Am J Ophthalmol. 1981 Nov;92(5):625–627. doi: 10.1016/s0002-9394(14)74653-7. [DOI] [PubMed] [Google Scholar]
  30. Winthrop S. R., Cleary P. E., Minckler D. S., Ryan S. J. Penetrating eye injuries: a histopathological review. Br J Ophthalmol. 1980 Nov;64(11):809–817. doi: 10.1136/bjo.64.11.809. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES