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. 1986 Aug;70(8):589–592. doi: 10.1136/bjo.70.8.589

Treatment and visual prognosis in Behçet's disease.

D Benezra, E Cohen
PMCID: PMC1040777  PMID: 3741823

Abstract

For the last decade we have observed and regularly followed 49 patients with the ocular type of Behçet's disease. Thirty-six patients were males and 13 were females. Regardless of whether the initial ocular presenting symptoms were in the anterior or posterior segment, both segments were involved within two years. Sterile hypopyon was recorded in 17 out of the 49 patients during the process of follow-up. In three of the patients hypopyon was the presenting symptom. Characteristically there was a lack of corneal or scleral involvement in the disease process. All patients responded initially to treatment with steroids, but 42 had a course of treatment with cytotoxic-immunosuppressive drugs for various lengths of time after 'resistance' to steroids developed. Although definitely effective in reducing the intensity of the ocular inflammatory processes, it is not clear yet whether these modes of treatment have any dramatic effect of the visual prognosis of the affected eyes. Despite intensive follow-up and treatment, loss of useful visual acuity has occurred in 74% of the eyes six to 10 years after the start of the ocular symptoms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BenEzra D., Nussenblatt R. Ocular manifestations of Behçet's disease. J Oral Pathol. 1978;7(6):431–435. doi: 10.1111/j.1600-0714.1978.tb01614.x. [DOI] [PubMed] [Google Scholar]
  2. Chajek T., Fainaru M. Behçet's disease. Report of 41 cases and a review of the literature. Medicine (Baltimore) 1975 May;54(3):179–196. doi: 10.1097/00005792-197505000-00001. [DOI] [PubMed] [Google Scholar]
  3. Colvard D. M., Robertson D. M., O'Duffy J. D. The ocular manifestations of Behçet's disease. Arch Ophthalmol. 1977 Oct;95(10):1813–1817. doi: 10.1001/archopht.1977.04450100115015. [DOI] [PubMed] [Google Scholar]
  4. Dinning W. J., Perkins E. S. Immunosuppressives in uveitis. A preliminary report of experience with chlorambucil. Br J Ophthalmol. 1975 Aug;59(8):397–403. doi: 10.1136/bjo.59.8.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FEIGENBAUM A. Description of Behçet's syndrome in the Hippocratic third book of endemic diseases. Br J Ophthalmol. 1956 Jun;40(6):355–357. doi: 10.1136/bjo.40.6.355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Godfrey W. A., Epstein W. V., O'Connor G. R., Kimura S. J., Hogan M. J., Nozik R. A. The use of chlorambucil in intractable idiopathic uveitis. Am J Ophthalmol. 1974 Sep;78(3):415–428. doi: 10.1016/0002-9394(74)90229-3. [DOI] [PubMed] [Google Scholar]
  7. Graham E. M., Sanders M. D., James D. G., Hamblin A., Kasp Grochowska E., Dumonde D. Cyclosporin A in the treatment of posterior uveitis. Trans Ophthalmol Soc U K. 1985;104(Pt 2):146–151. [PubMed] [Google Scholar]
  8. Haim S., Barzilai D., Hazani E. Involvement of veins in Behcet's syndrome. Br J Dermatol. 1971 Mar;84(3):238–241. doi: 10.1111/j.1365-2133.1971.tb14213.x. [DOI] [PubMed] [Google Scholar]
  9. Lehner T. Behçet's syndrome and autoimmunity. Br Med J. 1967 Feb 25;1(5538):465–467. doi: 10.1136/bmj.1.5538.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lehner T. Oral ulceration and Behçet's syndrome. Gut. 1977 Jun;18(6):491–511. doi: 10.1136/gut.18.6.491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MAMO J. G., BAGHDASSARIAN A. BEHCET'S DISEASE; A REPORT OF 28 CASES. Arch Ophthalmol. 1964 Jan;71:4–14. doi: 10.1001/archopht.1964.00970010020003. [DOI] [PubMed] [Google Scholar]
  12. Mamo J. G. Treatment of Behcet disease with chlorambucil. A follow-up report. Arch Ophthalmol. 1976 Apr;94(4):580–583. doi: 10.1001/archopht.1976.03910030274004. [DOI] [PubMed] [Google Scholar]
  13. Mason R. M., Barnes C. G. Behçet's syndrome with arthritis. Ann Rheum Dis. 1969 Mar;28(2):95–103. doi: 10.1136/ard.28.2.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Michelson J. B., Chisari F. V. Behçet's disease. Surv Ophthalmol. 1982 Jan-Feb;26(4):190–203. doi: 10.1016/0039-6257(82)90079-0. [DOI] [PubMed] [Google Scholar]
  15. Nussenblatt R. B., Palestine A. G., Chan C. C. Cyclosporin A therapy in the treatment of intraocular inflammatory disease resistant to systemic corticosteroids and cytotoxic agents. Am J Ophthalmol. 1983 Sep;96(3):275–282. doi: 10.1016/s0002-9394(14)77814-6. [DOI] [PubMed] [Google Scholar]
  16. Oshima Y., Shimizu T., Yokohari R., Matsumoto T., Kano K., Kagami T., Nagaya H. Clinical Studies on Behçet's Syndrome. Ann Rheum Dis. 1963 Jan;22(1):36–45. doi: 10.1136/ard.22.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Perkins E. S. Recent advances in the study of uveitis. Br J Ophthalmol. 1974 Apr;58(4):462–467. doi: 10.1136/bjo.58.4.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Porter R. Acute necrotizing retinitis in a patient receiving immunosuppressive therapy. Br J Ophthalmol. 1972 Jul;56(7):555–558. doi: 10.1136/bjo.56.7.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tricoulis D. Treatment of Behcet's disease with chlorambucil. Br J Ophthalmol. 1976 Jan;60(1):55–57. doi: 10.1136/bjo.60.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]

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