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. 1986 Sep;70(9):686–691. doi: 10.1136/bjo.70.9.686

Immunogenetic studies in retinoblastoma.

D F Roberts, M Duggan-Keen, G E Aherne, D R Long
PMCID: PMC1040800  PMID: 2944540

Abstract

In three unrelated families with transmitted retinoblastoma 43 members were tested for HLA-A, B, C, and DR antigens. On 18 patients, 16 unaffected relatives, and 16 controls, mixed lymphocyte cultures were carried out and the response to mitogens, phytohaemagglutinin, concanavalin A, and pokeweed mitogen examined. There were no associations of retinoblastoma with any HLA antigen. A reduction in T cell function is suggested by the results of the mitogen tests.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berlinger N. T., Good R. A. Suppressor cells in healthy relatives of patients with hereditary colon cancer. Cancer. 1980 Mar 15;45(5 Suppl):1112–1116. doi: 10.1002/1097-0142(19800315)45:5+<1112::aid-cncr2820451315>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  2. Bertrams J., Schildberg P., Höpping W., Böhme U., Albert E. HL-A antigens in retinoblastoma. Tissue Antigens. 1973;3(2):78–87. doi: 10.1111/j.1399-0039.1973.tb00981.x. [DOI] [PubMed] [Google Scholar]
  3. Char D. H., Christensen M., Goldberg L., Stein P. Immune complexes in retinoblastoma. Am J Ophthalmol. 1978 Sep;86(3):395–399. doi: 10.1016/0002-9394(78)90245-3. [DOI] [PubMed] [Google Scholar]
  4. Char D. H., Ellsworth R., Rabson A. S., Albert D. M., Herberman R. B. Cell-mediated immunity to a retinoblastoma tissue culture line in patients with retinoblastoma. Am J Ophthalmol. 1974 Jul;78(1):5–11. doi: 10.1016/0002-9394(74)90003-8. [DOI] [PubMed] [Google Scholar]
  5. Faguet G. B. Mechanisms of lymphocyte activation: the role of suppressor cells in the proliferative responses of chronic lymphatic leukemia lymphocytes. J Clin Invest. 1979 Jan;63(1):67–74. doi: 10.1172/JCI109280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gallie B. L., Dupont B., Whitsett C., Kitchen F. D., Ellsworth R. M., Good R. A. Histocompatibility typing in spontaneous regression of retinoblastoma. Prog Clin Biol Res. 1977;16:229–237. [PubMed] [Google Scholar]
  7. Hillinger S. M., Herzig G. P. Impaired cell-mediated immunity in Hodgkin's disease mediated by suppressor lymphocytes and monocytes. J Clin Invest. 1978 Jun;61(6):1620–1627. doi: 10.1172/JCI109082. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jerrells T. R., Dean J. H., Richardson G. L., McCoy J. L., Herberman R. B. Role of suppressor cells in depression of in vitro lymphoproliferative responses of lung cancer and breast cancer patients. J Natl Cancer Inst. 1978 Oct;61(4):1001–1009. [PubMed] [Google Scholar]
  9. Jones A. L. Immunogenetics of retinoblastoma. Trans Ophthalmol Soc U K. 1974;94(4):945–952. [PubMed] [Google Scholar]
  10. Schechter G. P., Soehnlen F. Monocyte-mediated inhibition of lymphocyte blastogenesis in Hodgkin disease. Blood. 1978 Aug;52(2):261–271. [PubMed] [Google Scholar]
  11. Stein P. C., Christensen M., Char D. H. Characterization of retinoblastoma immune complexes. Invest Ophthalmol Vis Sci. 1980 Mar;19(3):302–305. [PubMed] [Google Scholar]
  12. Twomey J. J., Laughter A. H., Farrow S., Douglass C. C. Hodgkin's disease. An immunodepleting and immunosuppressive disorder. J Clin Invest. 1975 Aug;56(2):467–475. doi: 10.1172/JCI108113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Zembala M., Mytar B., Popiela T., Asherson G. L. Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: the role of suppressor cells. Int J Cancer. 1977 May 15;19(5):605–613. doi: 10.1002/ijc.2910190503. [DOI] [PubMed] [Google Scholar]

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