Skip to main content
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1985 Dec;69(12):891–896. doi: 10.1136/bjo.69.12.891

Paralytic strabismus: the role of botulinum toxin.

J S Elston, J P Lee
PMCID: PMC1040877  PMID: 4084480

Abstract

Five adults with acute extraocular muscle palsies followed by limited recovery of muscle function were treated with injections of botulinum toxin A to the ipsilateral antagonist of the affected muscle. Three were cases of unilateral sixth nerve palsy, one of bilateral sixth nerve palsy, and one of third nerve palsy. After a period of paralysis, during which the strabismus was overcorrected, the injected muscle recovered and binocular sensory and motor functions were restored and have been maintained for periods of up to 21 months. The treatment is a safe and effective alternative to surgery, particularly in cases in which a general anaesthetic is not advisable.

Full text

PDF
891

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carlson M. R., Jampolsky A. An adjustable transposition procedure for abduction deficiences. Am J Ophthalmol. 1979 Mar;87(3):382–387. doi: 10.1016/0002-9394(79)90081-3. [DOI] [PubMed] [Google Scholar]
  2. Dolly J. O., Black J., Williams R. S., Melling J. Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalization. Nature. 1984 Feb 2;307(5950):457–460. doi: 10.1038/307457a0. [DOI] [PubMed] [Google Scholar]
  3. Duchen L. W. An electron microscopic study of the changes induced by botulinum toxin in the motor end-plates of slow and fast skeletal muscle fibres of the mouse. J Neurol Sci. 1971 Sep;14(1):47–60. doi: 10.1016/0022-510x(71)90129-8. [DOI] [PubMed] [Google Scholar]
  4. Elston J. S., Lee J. P., Powell C. M., Hogg C., Clark P. Treatment of strabismus in adults with botulinum toxin A. Br J Ophthalmol. 1985 Oct;69(10):718–724. doi: 10.1136/bjo.69.10.718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Elston J. S. Traumatic third nerve palsy. Br J Ophthalmol. 1984 Aug;68(8):538–543. doi: 10.1136/bjo.68.8.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Rush J. A., Younge B. R. Paralysis of cranial nerves III, IV, and VI. Cause and prognosis in 1,000 cases. Arch Ophthalmol. 1981 Jan;99(1):76–79. doi: 10.1001/archopht.1981.03930010078006. [DOI] [PubMed] [Google Scholar]
  7. Scott A. B. Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery. Ophthalmology. 1980 Oct;87(10):1044–1049. doi: 10.1016/s0161-6420(80)35127-0. [DOI] [PubMed] [Google Scholar]
  8. Scott A. B. The faden operation: mechanical effects. Am Orthopt J. 1977;27:44–47. [PubMed] [Google Scholar]
  9. Stanworth A. Defects of ocular movement and fusion after head injury. Br J Ophthalmol. 1974 Mar;58(3):266–271. doi: 10.1136/bjo.58.3.266. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES