Abstract
A blind randomised cross-over study was conducted on 10 patients (20 eyes) to compare the effect in patients with open-angle glaucoma of metipranolol 0.3% with that of timolol 0.25% on intraocular pressure following one month's topical instillation with each preparation alone. There was no statistically significant difference in intraocular pressure reduction between these two preparations, and the ocular tolerance of both was good. There was no significant difference in the blood pressure, pulse, or pupil diameters of patients receiving either preparation.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hall R. A., Robson R. D., Share N. N. Timolol maleate, a new beta-adrenergic receptor blocking agent. Arch Int Pharmacodyn Ther. 1975 Feb;213(2):251–263. [PubMed] [Google Scholar]
- Katz I. M., Hubbard W. A., Getson A. J., Gould A. L. Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. Invest Ophthalmol. 1976 Jun;15(6):489–492. [PubMed] [Google Scholar]
- Obstbaum S. A., Galin M. A., Katz I. M. Trimolol: effect on intraocular pressure in chronic open-angle glaucoma. Ann Ophthalmol. 1978 Oct;10(10):1347–1351. [PubMed] [Google Scholar]
- Radius R. L., Diamond G. R., Pollack I. P., Langham M. E. Timolol. A new drug for management of chronic simple glaucoma. Arch Ophthalmol. 1978 Jun;96(6):1003–1008. doi: 10.1001/archopht.1978.03910050527005. [DOI] [PubMed] [Google Scholar]
- Zimmerman T. J., Kaufman H. E. Timolol. A beta-adrenergic blocking agent for the treatment of glaucoma. Arch Ophthalmol. 1977 Apr;95(4):601–604. doi: 10.1001/archopht.1977.04450040067008. [DOI] [PubMed] [Google Scholar]