Abstract
High water content intracorneal implants were fabricated from Vistamarc hydrogel (Vistakon, Inc.) at 58%, 68%, and 72% water content and a range of powers from +7.25 to +17.00 dioptres. The Barraquer microkeratome technique was used to implant the lens at 59.0 +/- 9% (+/- SD) depth in the corneas of 14 rhesus monkey eyes. The contralateral eye served as a control. Three eyes were lost to the study because of complications. The remaining 11 animals were followed up for 51 +/- 2 weeks with the refractive yield being 118 +/- 34% and the keratometric yield being 92 +/- 30%. The measured and theoretically expected refractive changes have a linear regression line correlation coefficient of 0.74, whereas the respective keratometric data had a correlation coefficient of 0.04. The measured refraction became stable within 2 to 3 dioptres after 20 postoperative weeks. The hydrogels were well tolerated within the corneal tissue. There was a minimum of interface problems except along the edge of the implant. Implants with abruptly cut edges versus a fine wedge tended to have more light scattering collagen at the implant margin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Binder P. S., Zavala E. Y., Deg J. K., Baumgartner S. D. Hydrophilic lenses for refractive keratoplasty: the use of factory lathed materials. CLAO J. 1984 Jan-Mar;10(1):105–111. [PubMed] [Google Scholar]
- McCarey B. E., Andrews D. M. Refractive keratoplasty with intrastromal hydrogel lenticular implants. Invest Ophthalmol Vis Sci. 1981 Jul;21(1 Pt 1):107–115. [PubMed] [Google Scholar]
- McCarey B. E., van Rij G., Beekhuis W. H., Waring G. O., 3rd Hydrogel keratophakia: a freehand pocket dissection in the monkey model. Br J Ophthalmol. 1986 Mar;70(3):187–191. doi: 10.1136/bjo.70.3.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Watsky M. A., McCarey B. E., Beekhuis W. H. Predicting refractive alterations with hydrogel keratophakia. Invest Ophthalmol Vis Sci. 1985 Feb;26(2):240–243. [PubMed] [Google Scholar]