Abstract
The serum of 893 uveitis patients was examined for various non-ocular specific autoantibodies. Overall 40.8% of patients had detectable levels of autoantibodies in their sera. These comprised antibodies to smooth muscle (23.1%), nuclear material (12.7%), gastric parietal cell (3.0%), reticulin (1.8%), and mitochondria (0.2%). When the patients were distributed into nine selected categories of uveitis, only patients with one distinct clinical entity showed a statistically significant difference in the presence of the above serum autoantibodies as compared with healthy individuals. They were patients with uveitis associated with juvenile chronic arthritis, among whom antinuclear antibody was detected in 77% (p less than 0.001). Testing for the presence of circulating non-ocular specific autoantibodies appears to be of little or no value in the routine screening of uveitis patients, but it may be helpful in the diagnosis and management of certain individual cases, such as juvenile chronic arthritis, or as a research tool to advance understanding of pathogenetic mechanisms.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bottazzo G. F., Pujol-Borrell R., Hanafusa T., Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet. 1983 Nov 12;2(8359):1115–1119. doi: 10.1016/s0140-6736(83)90629-3. [DOI] [PubMed] [Google Scholar]
- Char D. H., Stein P., Masi R., Christensen M. Immune complexes in uveitis. Am J Ophthalmol. 1979 May;87(5):678–681. doi: 10.1016/0002-9394(79)90303-9. [DOI] [PubMed] [Google Scholar]
- Cooke A., Lydyard P. M., Roitt I. M. Autoimmunity and idiotypes. Lancet. 1984 Sep 29;2(8405):723–725. doi: 10.1016/s0140-6736(84)92628-x. [DOI] [PubMed] [Google Scholar]
- Dumonde D. C., Kasp-Grochowska E., Banga J. P., Sanders M. D., Graham E., Stanford M. A., Faure J. P., De Kozak Y., Van Tuyen V. Autoimmune mechanisms in inflammatory eye disease. Trans Ophthalmol Soc U K. 1985;104(Pt 3):232–238. [PubMed] [Google Scholar]
- Kanski J. J., Shun-Shin G. A. Systemic uveitis syndromes in childhood: an analysis of 340 cases. Ophthalmology. 1984 Oct;91(10):1247–1252. doi: 10.1016/s0161-6420(84)34177-x. [DOI] [PubMed] [Google Scholar]
- Martenet A. C. Role of viruses in uveitis. Trans Ophthalmol Soc U K. 1981 Sep;101(3):308–311. [PubMed] [Google Scholar]
- McCoy R., White L., Tait B., Ebringer R. Serum immunoglobulins in acute anterior uveitis. Br J Ophthalmol. 1984 Nov;68(11):807–810. doi: 10.1136/bjo.68.11.807. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murray P. I., Rahi A. H. New concepts in the control of ocular inflammation. Trans Ophthalmol Soc U K. 1985;104(Pt 2):152–158. [PubMed] [Google Scholar]
- Ohno S., Char D. H., Kimura S. J., O'Connor G. R. HLA antigens and antinuclear antibody titres in juvenile chronic iridocyclitis. Br J Ophthalmol. 1977 Jan;61(1):59–61. doi: 10.1136/bjo.61.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plotz P. H. Autoantibodies are anti-idiotype antibodies to antiviral antibodies. Lancet. 1983 Oct 8;2(8354):824–826. doi: 10.1016/s0140-6736(83)90740-7. [DOI] [PubMed] [Google Scholar]
- Rahi A. H., Holborow E. J., Perkins E. S., Gungen Y. Y., Dinning W. J. Immunological investigations in uveitis. Trans Ophthalmol Soc U K. 1976 Apr;96(1):113–122. [PubMed] [Google Scholar]
- Saari K. M. The International Uveitis Study Group. Acta Ophthalmol Suppl. 1984;163:21–28. doi: 10.1111/j.1755-3768.1984.tb08470.x. [DOI] [PubMed] [Google Scholar]
- Wakefield D., Penny R. Cell-mediated immune response to chlamydia in anterior uveitis: role of HLA B27. Clin Exp Immunol. 1983 Feb;51(2):191–196. [PMC free article] [PubMed] [Google Scholar]
- Welsh J., Avakian H., Ebringer A. Uveitis, vitreous humour, and klebsiella. II. Cross-reactivity studies with radioimmunoassay. Br J Ophthalmol. 1981 May;65(5):323–328. doi: 10.1136/bjo.65.5.323. [DOI] [PMC free article] [PubMed] [Google Scholar]