Abstract
Ninety-three consecutive patients with adult chlamydial ophthalmia were treated with four different regimens of oral doxycycline. In patients treated with a single dose of 5 mg/kg of body weight (300 mg) of doxycycline the severity of clinical signs was reduced, and in half of the patients shedding of the infective agent was stopped. Treatment with a weekly dose of 300 mg of doxycycline for three weeks or a daily dose of 1.5 mg/kg of body weight (100 mg) for one week produced a clinical and microbiological cure in 100% of patients. However, in some of these patients mild to moderate papillary responses were present up to six months from completion of the treatment. The best results were obtained with a daily dose of 100 mg for two weeks, which produced rapid clinical and microbiological cure in all patients.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DUNLOP E. M., JONES B. R., AL-HUSSAINI M. K. GENITAL INFECTION IN ASSOCIATION WITH TRIC VIRUS INFECTION OF THE EYE. III. CLINICAL AND OTHER FINDINGS. PRELIMINARY REPORT. Br J Vener Dis. 1964 Mar;40:33–42. doi: 10.1136/sti.40.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Darougar S., Jones B. R. Conjunctival swabbing for the isolation of TRIC agent (Chlamydia). Br J Ophthalmol. 1971 Sep;55(9):585–590. doi: 10.1136/bjo.55.9.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Darougar S., Jones B. R., Kinnison J. R., Vaughan-Jackson J. D., Dunlop E. M. Chlamydial infection. Advances in the diagnostic isolation of Chlamydia, including TRIC agent, from the eye, genital tract, and rectum. Br J Vener Dis. 1972 Dec;48(6):416–420. doi: 10.1136/sti.48.6.416. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Darougar S., Jones B. R., Viswalingam N., Poirier R. H., Allami J., Houshmand A., Farahmandian M. A., Gibson J. A. Family-based suppressive intermittent therapy of hyperendemic trachoma with topical oxytetracycline or oral doxycycline. Br J Ophthalmol. 1980 Apr;64(4):291–295. doi: 10.1136/bjo.64.4.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Darougar S., Viswalingam M., Treharne J. D., Kinnison J. R., Jones B. R. Treatment of TRIC infection of the eye with rifampicin or chloramphenicol. Br J Ophthalmol. 1977 Apr;61(4):255–259. doi: 10.1136/bjo.61.4.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Darougar S., Viswalingam N., El-Sheikh H., Hunter P. A., Yearsley P. A double-blind comparison of topical therapy of chlamydial ocular infection (TRIC infection) with rifampicin or chlortetracycline. Br J Ophthalmol. 1981 Aug;65(8):549–552. doi: 10.1136/bjo.65.8.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gordon F. B., Harper I. A., Quan A. L., Treharne J. D., Dwyer R. S., Garland J. A. Detection of Chlamydia (Bedsonia) in certain infections of man. I. Laboratory procedures: comparison of yolk sac and cell culture for detection and isolation. J Infect Dis. 1969 Oct;120(4):451–462. doi: 10.1093/infdis/120.4.451. [DOI] [PubMed] [Google Scholar]
- Ingerslev H. J., Møller B. R., Mårdh P. A. Chlamydia trachomatis in acute and chronic endometritis. Scand J Infect Dis Suppl. 1982;32:59–63. [PubMed] [Google Scholar]
- JONES B. R., AL-HUSSAINI M. K., DUNLOP E. M. GENITAL INFECTION IN ASSOCIATION WITH TRIC VIRUS INFECTION OF THE EYE. I. ISOLATION OF VIRUS FROM URETHRA, CERVIX, AND EYE. PRELIMINARY REPORT. Br J Vener Dis. 1964 Mar;40:19–24. doi: 10.1136/sti.40.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones B. R. The prevention of blindness from trachoma. Trans Ophthalmol Soc U K. 1975 Apr;95(1):16–33. [PubMed] [Google Scholar]
- Weström L., Mårdh P. A. Chlamydial salpingitis. Br Med Bull. 1983 Apr;39(2):145–150. doi: 10.1093/oxfordjournals.bmb.a071806. [DOI] [PubMed] [Google Scholar]