Abstract
This study documents for the first time light and electron microscopical changes in the retinal pigment epithelium (RPE) following treatment with high dose desferrioxamine for systemic iron overload. The changes include loss of microvilli from the apical surface, patchy depigmentation, vacuolation of the cytoplasm, swelling and calcification of mitochondria, and disorganisation of the plasma membrane. In addition, Bruch's membrane overlying degenerate RPE cells appeared abnormally thickened owing to the accumulation of large amounts of mature elastic fibres, pre-elastic oxytalan, and long spacing collagen. The specificity of these changes and the mechanism of toxicity are discussed.
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- Alexander R. A., Garner A. Elastic and precursor fibres in the normal human eye. Exp Eye Res. 1983 Feb;36(2):305–315. doi: 10.1016/0014-4835(83)90015-5. [DOI] [PubMed] [Google Scholar]
- Anderson D. H., Stern W. H., Fisher S. K., Erickson P. A., Borgula G. A. Retinal detachment in the cat: the pigment epithelial-photoreceptor interface. Invest Ophthalmol Vis Sci. 1983 Jul;24(7):906–926. [PubMed] [Google Scholar]
- Ashburn F. S., Jr, Pilkerton A. R., Rao N. A., Marak G. E. The effects of iodate and iodoacetate on the retinal adhesion. Invest Ophthalmol Vis Sci. 1980 Dec;19(12):1427–1432. [PubMed] [Google Scholar]
- BICKEL H., GAEUMANN E., KELLER-SCHIERLEIN W., PRELOG V., VISCHER E., WETTSTEIN A., ZAEHNER H. [On iron-containing growth factors, sideramines, and their antagonists, the iron-containing antibiotics, sideromycins]. Experientia. 1960 Apr 15;16:129–133. doi: 10.1007/BF02157712. [DOI] [PubMed] [Google Scholar]
- Bloomfield S. E., Markenson A. L., Miller D. R., Peterson C. M. Lens opacities in thalassemia. J Pediatr Ophthalmol Strabismus. 1978 May-Jun;15(3):154–156. doi: 10.3928/0191-3913-19780501-08. [DOI] [PubMed] [Google Scholar]
- Davies S. C., Marcus R. E., Hungerford J. L., Miller M. H., Arden G. B., Huehns E. R. Ocular toxicity of high-dose intravenous desferrioxamine. Lancet. 1983 Jul 23;2(8343):181–184. doi: 10.1016/s0140-6736(83)90170-8. [DOI] [PubMed] [Google Scholar]
- GOURAS P., GUNKEL R. D. THE EOG IN CHLOROQUINE AND OTHER RETINOPATHIES. Arch Ophthalmol. 1963 Nov;70:629–639. doi: 10.1001/archopht.1963.00960050631009. [DOI] [PubMed] [Google Scholar]
- Rao S. S., Satapathy M., Sitaramayya A. Copper metabolism in retinitis pigmentosa patients. Br J Ophthalmol. 1981 Feb;65(2):127–130. doi: 10.1136/bjo.65.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosenthal A. R., Kolb H., Bergsma D., Huxsoll D., Hopkins J. L. Chloroquine retinopathy in the rhesus monkey. Invest Ophthalmol Vis Sci. 1978 Dec;17(12):1158–1175. [PubMed] [Google Scholar]
- Sakuragawa M., Kuwabara T. The pigment epithelium of the monkey. Topographic study by scanning and transmission electron microscopy. Arch Ophthalmol. 1976 Feb;94(2):285–292. doi: 10.1001/archopht.1976.03910030139013. [DOI] [PubMed] [Google Scholar]
- Wise J. B. Treatment of experimental siderosis bulbi, vitreous hemorrhage, and corneal blood staining with deferoxamine. Arch Ophthalmol. 1966 May;75(5):698–707. doi: 10.1001/archopht.1966.00970050700023. [DOI] [PubMed] [Google Scholar]