Abstract
Some haematological and rheological features were compared in 27 age and sex matched pairs of patients (15 male, 12 female) with homozygous sickle cell (SS) disease with and without proliferative sickle retinopathy (PSR). Significant haematological differences between the groups were a higher haemoglobin and a lower fetal haemoglobin in PSR positive males and a higher MCHC in PSR positive females. The plasma viscosity and characteristics of erythrocyte filterability did not differ between those with and those without PSR, although PSR positive males had a significantly higher whole blood viscosity when measured at high shear and at the patient's own packed cell volume.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Condon P. I., Hayes R. J., Serjeant G. R. Retinal and choroidal neovascularization in sickle cell disease. Trans Ophthalmol Soc U K. 1980 Sep;100(3):434–439. [PubMed] [Google Scholar]
- Condon P. I., Serjeant G. R. Behaviour of untreated proliferative sickle retinopathy. Br J Ophthalmol. 1980 Jun;64(6):404–411. doi: 10.1136/bjo.64.6.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Condon P. I., Serjeant G. R. Ocular findings in homozygous sickle cell anemia in Jamaica. Am J Ophthalmol. 1972 Apr;73(4):533–543. doi: 10.1016/0002-9394(72)90005-0. [DOI] [PubMed] [Google Scholar]
- Hayes R. J., Condon P. I., Serjeant G. R. Haematological factors associated with proliferative retinopathy in homozygous sickle cell disease. Br J Ophthalmol. 1981 Jan;65(1):29–35. doi: 10.1136/bjo.65.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
- INGRAM G. I. A suggested schedule for the rapid investigation of acute haemostatic failure. J Clin Pathol. 1961 Jul;14:356–360. doi: 10.1136/jcp.14.4.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Serjeant B. E., Mason K. P., Condon P. I., Hayes R. J., Kenny M. W., Stuart J., Serjeant G. R. Blood rheology and proliferative retinopathy in sickle cell-haemoglobin C disease. Br J Ophthalmol. 1984 May;68(5):325–328. doi: 10.1136/bjo.68.5.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Serjeant B. E., Mason K. P., Kenny M. W., Stuart J., Higgs D. R., Weatherall D. J., Hayes R. J., Serjeant G. R. Effect of alpha thalassaemia on the rheology of homozygous sickle cell disease. Br J Haematol. 1983 Nov;55(3):479–486. doi: 10.1111/j.1365-2141.1983.tb02163.x. [DOI] [PubMed] [Google Scholar]