Abstract
Topical levobunolol 0.5% was compared with topical metipranolol 0.6% for efficacy, safety, and comfort in 46 patients with open angle glaucoma or ocular hypertension. The study was of parallel design, randomised, double-masked, and of three months' duration. After a washout interval the study medications were instilled twice daily in both eyes. The overall mean decrease in intraocular pressure (IOP) was approximately 7 mmHg in both groups. More than 90% of patients in both groups successfully completed the study. Both agents caused slight decreases in heart rate and blood pressure. More complaints of burning and stinging were reported in the metipranolol group than in the levobunolol group. This three-month, 46-patient study showed levobunolol 0.5% and metipranolol 0.6% to be similarly effective ocular hypotensive agents.
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Selected References
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- Duzman E., Ober M., Scharrer A., Leopold I. H. A clinical evaluation of the effects of topically applied levobunolol and timolol on increased intraocular pressure. Am J Ophthalmol. 1982 Sep;94(3):318–327. doi: 10.1016/0002-9394(82)90357-9. [DOI] [PubMed] [Google Scholar]
- Kruse W. Metipranolol--ein neuer Betarezeptorenblocker. Klin Monbl Augenheilkd. 1983 Jun;182(6):582–584. doi: 10.1055/s-2008-1054859. [DOI] [PubMed] [Google Scholar]
- Mills K. B., Wright G. A blind randomised cross-over trial comparing metipranolol 0.3% with timolol 0.25% in open-angle glaucoma: a pilot study. Br J Ophthalmol. 1986 Jan;70(1):39–42. doi: 10.1136/bjo.70.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ober M., Scharrer A., Novack G. D., Lue J. C. Lokale subjektive Verträglichkeit von Levobunolol und Metipranolol in einer Doppelblind-Vergleichsstudie bei Patienten mit erhöhtem intraokularem Druck. Ophthalmologica. 1986;192(3):159–164. doi: 10.1159/000309631. [DOI] [PubMed] [Google Scholar]
- Partamian L. G., Kass M. A., Gordon M. A dose-response study of the effect of levobunolol on ocular hypertension. Am J Ophthalmol. 1983 Feb;95(2):229–232. doi: 10.1016/0002-9394(83)90018-1. [DOI] [PubMed] [Google Scholar]
- Schoene R. B., Abuan T., Ward R. L., Beasley C. H. Effects of topical betaxolol, timolol, and placebo on pulmonary function in asthmatic bronchitis. Am J Ophthalmol. 1984 Jan;97(1):86–92. doi: 10.1016/0002-9394(84)90450-1. [DOI] [PubMed] [Google Scholar]
- Spiritus E. M., Casciari R. Effects of topical betaxolol, timolol, and placebo on pulmonary function in asthmatic bronchitis. Am J Ophthalmol. 1985 Sep 15;100(3):492–494. doi: 10.1016/0002-9394(85)90532-x. [DOI] [PubMed] [Google Scholar]
- Van Buskirk E. M., Fraunfelder F. T. Ocular beta-blockers and systemic effects. Am J Ophthalmol. 1984 Nov;98(5):623–624. doi: 10.1016/0002-9394(84)90250-2. [DOI] [PubMed] [Google Scholar]