Abstract
A 79-year-old woman developed an orbital mass five and a half years after excision of a cutaneous melanoma from the side of the nose. The initial orbital biopsy was interpreted histopathologically as a malignant fibrous histiocytoma, but special stains and electron microscopy showed it to be a desmoplastic malignant melanoma which had apparently spread to the orbit from the prior skin lesion by neurotropic mechanisms. The occurrence of a desmoplastic neurotropic melanoma in the orbit has not been previously recognised. The problems in the clinical and pathological diagnosis of this rare type of melanoma are discussed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berry R. B., Subbuswamy S. G., Hackett M. E. Desmoplastic malignant melanoma: the first British report. Br J Plast Surg. 1982 Jul;35(3):324–327. doi: 10.1016/s0007-1226(82)90121-7. [DOI] [PubMed] [Google Scholar]
- Bryant E., Ronan S. G., Felix E. L., Manaligod J. R. Desmoplastic malignant melanoma: a study by conventional and electron microscopy. Am J Dermatopathol. 1982 Oct;4(5):467–474. doi: 10.1097/00000372-198210000-00016. [DOI] [PubMed] [Google Scholar]
- Chasle J., Borel B., Van Hoa L., Mandard A. M. Le mélanome malin desmoplastique. A propos d'une observation. Arch Anat Cytol Pathol. 1979;27(6):389–393. [PubMed] [Google Scholar]
- Conley J., Lattes R., Orr W. Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma). Cancer. 1971 Oct;28(4):914–936. doi: 10.1002/1097-0142(1971)28:4<914::aid-cncr2820280415>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- DiMaio S. M., Mackay B., Smith J. L., Jr, Dickersin G. R. Neurosarcomatous transformation in malignant melanoma: an ultrastructural study. Cancer. 1982 Dec 1;50(11):2345–2354. doi: 10.1002/1097-0142(19821201)50:11<2345::aid-cncr2820501121>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
- Frolow G. R., Shapiro L., Brownstein M. H. Desmoplastic malignant melanoma. Arch Dermatol. 1975 Jun;111(6):753–754. [PubMed] [Google Scholar]
- From L., Hanna W., Kahn H. J., Gruss J., Marks A., Baumal R. Origin of the desmoplasia in desmoplastic malignant melanoma. Hum Pathol. 1983 Dec;14(12):1072–1080. doi: 10.1016/s0046-8177(83)80264-0. [DOI] [PubMed] [Google Scholar]
- Man D., Weiner L. J., Reiman H. M., Jr Desmoplastic malignant melanoma: a case report. Br J Plast Surg. 1981 Jan;34(1):79–82. doi: 10.1016/0007-1226(81)90105-3. [DOI] [PubMed] [Google Scholar]
- Noodleman F. R., Roth R. J., Miller A. C., Nickoloff B. J. Neurotropic malignant melanoma: a novel treatment approach combining modified microscopically controlled surgery and S100 immunohistochemical staining. J Dermatol Surg Oncol. 1985 Nov;11(11):1123–1127. doi: 10.1111/j.1524-4725.1985.tb01400.x. [DOI] [PubMed] [Google Scholar]
- Reed R. J., Leonard D. D. Neurotropic melanoma. A variant of desmoplastic melanoma. Am J Surg Pathol. 1979 Aug;3(4):301–311. doi: 10.1097/00000478-197908000-00002. [DOI] [PubMed] [Google Scholar]
- Shields J. A., Font R. L. Meibomian gland carcinoma presenting as a lacrimal gland tumor. Arch Ophthalmol. 1974 Oct;92(4):304–306. doi: 10.1001/archopht.1974.01010010314009. [DOI] [PubMed] [Google Scholar]
- Sutula F. C., Dortzbach R. K., Bolles J. C. Desmoplastic malignant melanoma of the upper eyelid. Ann Ophthalmol. 1982 Feb;14(2):141–143. [PubMed] [Google Scholar]
- Valensi Q. J. Desmoplastic malignant melanoma: a report on two additional cases. Cancer. 1977 Jan;39(1):286–292. doi: 10.1002/1097-0142(197701)39:1<286::aid-cncr2820390144>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
- Warner T. F., Ford C. N., Hafez G. R. Neurotropic melanoma of the face invading the maxillary nerve. J Cutan Pathol. 1985 Dec;12(6):520–527. doi: 10.1111/j.1600-0560.1985.tb00451.x. [DOI] [PubMed] [Google Scholar]