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. 1987 Aug;71(8):585–592. doi: 10.1136/bjo.71.8.585

Experimental posterior uveitis. I: A clinical, angiographic, and pathological study.

M R Stanford 1, E C Brown 1, E Kasp 1, E M Graham 1, M D Sanders 1, D C Dumonde 1
PMCID: PMC1041237  PMID: 3651374

Abstract

The clinical, angiographic, and histopathological features of experimental posterior uveitis in the black hooded Lister rat are described. This mild form of experimental allergic uveoretinitis (EAU) is induced by sensitisation with retinal S antigen in Freund's complete adjuvant, and the inflammation produced is confined to the posterior segment of the eye. This allows for the first time precise photographic and angiographic documentation of the evolution of clinical signs, because there is minimal clouding of the vitreous by inflammatory cells. Clinically the disease is characterised by the appearance of disc oedema and periphlebitis, followed by focal infiltrates in the deep retinal layers, with eventual atrophy of the pigment epithelium. Histologically, retinal vasculitis is associated with focal mononuclear cell infiltration and necrosis of the photoreceptor layers. This model closely resembles the clinical features of idiopathic retinal vasculitis seen in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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