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. 1988 Jun;72(6):469–472. doi: 10.1136/bjo.72.6.469

A study of the effects of four concentrations of D-timolol, 0.25% L-timolol, and placebo on intraocular pressure on patients with raised intraocular pressure.

K B Mills 1, N J Jacobs 1, R Vogel 1
PMCID: PMC1041485  PMID: 3291941

Abstract

The intraocular pressure lowering effect in 30 patients with raised intraocular pressure and open angles following a single application in a randomised double-masked fashion of four concentrations of D-timolol (0.25%, 0.5%, 1.0%, and 2.0%), 0.25% L-timolol, and placebo are presented. The percentage reduction in intraocular pressure after four hours following single-drop instillation range from 20% to 25% in the D-timolol group, 32% in the L-timolol group, and only 8% in the placebo group of treated eyes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Katz I. M., Hubbard W. A., Getson A. J., Gould A. L. Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. Invest Ophthalmol. 1976 Jun;15(6):489–492. [PubMed] [Google Scholar]
  2. Keates E. U., Stone R. The effect of d-timolol on intraocular pressure in patients with ocular hypertension. Am J Ophthalmol. 1984 Jul 15;98(1):73–78. doi: 10.1016/0002-9394(84)90191-0. [DOI] [PubMed] [Google Scholar]
  3. Liu J. H., Bartels S. P., Neufeld A. H. Effects of l- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits. Invest Ophthalmol Vis Sci. 1983 Sep;24(9):1276–1282. [PubMed] [Google Scholar]
  4. Mills K. B. Blind randomised non-crossover long-term trial comparing topical timolol 0.25% with timolol 0.5% in the treatment of simple chronic glaucoma. Br J Ophthalmol. 1983 Apr;67(4):216–219. doi: 10.1136/bjo.67.4.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Share N. N., Lotti V. J., Gautheron P., Schmitt C., Gross D. M., Hall R. A., Stone C. A. R-enantiomer of timolol: a potential selective ocular antihypertensive agent. Graefes Arch Clin Exp Ophthalmol. 1984;221(5):234–238. doi: 10.1007/BF02134145. [DOI] [PubMed] [Google Scholar]
  6. Wasson B. K., Gibson W. K., Stuart R. S., Williams H. W., Yates C. H. -adrenergic blocking agents. 3-(3-Substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazoles. J Med Chem. 1972 Jun;15(6):651–655. doi: 10.1021/jm00276a022. [DOI] [PubMed] [Google Scholar]
  7. Zimmerman T. J., Kaufman H. E. Timolol. A beta-adrenergic blocking agent for the treatment of glaucoma. Arch Ophthalmol. 1977 Apr;95(4):601–604. doi: 10.1001/archopht.1977.04450040067008. [DOI] [PubMed] [Google Scholar]

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