Abstract
The consensual ophthalmotonic reaction describes the phenomenon whereby alteration of the intraocular pressure in one eye is accompanied by a corresponding pressure change in the contralateral eye. Thirteen normal and thirteen ocular hypertensive subjects received 0.5% timolol, 2% pilocarpine, 1% adrenaline, or saline uniocularly with saline to the other eye under double blind, randomised conditions. Intraocular pressure was measured by applanation tonometry at 0, 30, 60, 120, and 240 minutes. Falls in pressure were found in both treated and consensual eyes for all treatments in both subject groups. A linear relationship between the fall in pressure in the treated eye and that in the consensual eye was found for timolol and pilocarpine but not for adrenaline.
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Selected References
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- Beitch B. R., Eakins K. E. The effects of prostaglandins on the intraocular pressure of the rabbit. Br J Pharmacol. 1969 Sep;37(1):158–167. doi: 10.1111/j.1476-5381.1969.tb09533.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davson H., Quilliam J. P. THE EFFECTS OF NITROGEN MUSTARD ON THE PERMEABILITY OF THE BLOOD-AQUEOUS HUMOUR BARRIER TO EVANS BLUE: An instance of the influence of a lesion in one eye on the susceptibility of the other. Br J Ophthalmol. 1947 Dec;31(12):717–721. doi: 10.1136/bjo.31.12.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Demailly P., Pigot C., Arrata M. Action d'une instillation quotidienne de timolol sur la courbe tensionnelle nycthémérale de sujets porteurs d'un glaucome à angle ouvert. J Fr Ophtalmol. 1978 Dec;1(12):739–742. [PubMed] [Google Scholar]
- Gwin R. M., Gelatt K. N., Gum G. G., Peiffer R. L., Jr Effects of topical 1-epinephrine and dipivalyl epinephrine on intraocular pressure and pupil size in the normotensive and glaucomatous Beagle. Am J Vet Res. 1978 Jan;39(1):83–86. [PubMed] [Google Scholar]
- Langham M. E., Diggs E. Beta-adrenergic responses in the eyes of rabbits, primates, and man. Exp Eye Res. 1974 Sep;19(3):281–295. doi: 10.1016/0014-4835(74)90147-x. [DOI] [PubMed] [Google Scholar]
- Neetens A., Rubbens M. C., Van Rompaey J., Hendrata Y. Intraocular pressure lowering effect of timolol in the fellow untreated eye. Bull Soc Belge Ophtalmol. 1979;186:39–46. [PubMed] [Google Scholar]
- PERKINS E. S. Influence of the fifth cranial nerve on the intra-ocular pressure of the rabbit eye. Br J Ophthalmol. 1957 May;41(5):257–300. doi: 10.1136/bjo.41.5.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PRIJOT E. L., STONE H. H. On the ophthalmotonic consensual reaction and its relationship to aqueous humor dynamics. Am J Ophthalmol. 1956 Jul;42(1):50–58. doi: 10.1016/0002-9394(56)90007-1. [DOI] [PubMed] [Google Scholar]
- Radius R. L., Diamond G. R., Pollack I. P., Langham M. E. Timolol. A new drug for management of chronic simple glaucoma. Arch Ophthalmol. 1978 Jun;96(6):1003–1008. doi: 10.1001/archopht.1978.03910050527005. [DOI] [PubMed] [Google Scholar]
- STOCKER F. W. On changes in intraocular pressure after application of the tonometer; in the same eye and in the other eye. Am J Ophthalmol. 1958 Feb;45(2):192–196. doi: 10.1016/0002-9394(58)90643-3. [DOI] [PubMed] [Google Scholar]
- Schwartz A. L., Whitten M. E., Bleiman B., Martin D. Argon laser trabecular surgery in uncontrolled phakic open angle glaucoma. Ophthalmology. 1981 Mar;88(3):203–212. doi: 10.1016/s0161-6420(81)35048-9. [DOI] [PubMed] [Google Scholar]
- Smith S. E., Smith S. A., Reynolds F., Whitmarsh V. B. Ocular and cardiovascular effects of local and systemic pindolol. Br J Ophthalmol. 1979 Jan;63(1):63–66. doi: 10.1136/bjo.63.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Willetts G. S. Autonomic effector drugs and the normal human eye. Am J Ophthalmol. 1969 Aug;68(2):216–223. doi: 10.1016/0002-9394(69)94063-x. [DOI] [PubMed] [Google Scholar]
- Zimmerman T. J., Kaufman H. E. Timolol. A beta-adrenergic blocking agent for the treatment of glaucoma. Arch Ophthalmol. 1977 Apr;95(4):601–604. doi: 10.1001/archopht.1977.04450040067008. [DOI] [PubMed] [Google Scholar]
