Abstract
Three hundred and fifteen patients with anterior uveitis associated with juvenile chronic arthritis (JCA) were studied in order to identify the various risk factors for uveitis. Girls were more susceptible to uveitis than boys by a ratio of 3:1. In 94% of cases the uveitis was diagnosed after the development of arthritis. The risk of uveitis was small after seven or more years had elapsed from the onset of arthritis. Patients with pauciarticular onset JCA had the highest risk of uveitis and systemic onset patients the least risk. The presence of circulating antinuclear antibody was also an important marker for an increased risk of uveitis. A regimen for routine screening of patients is suggested.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ansell B. M. Heberden Oration, 1977. Chronic arthritis in childhood. Ann Rheum Dis. 1978 Apr;37(2):107–120. doi: 10.1136/ard.37.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chylack L. T., Jr, Bienfang D. C., Bellows A. R., Stillman J. S. Ocular manifestations of juvenile rheumatoid arthritis. Am J Ophthalmol. 1975 Jun;79(6):1026–1033. doi: 10.1016/0002-9394(75)90689-3. [DOI] [PubMed] [Google Scholar]
- Kanski J. J. Anterior uveitis in juvenile rheumatoid arthritis. Arch Ophthalmol. 1977 Oct;95(10):1794–1797. doi: 10.1001/archopht.1977.04450100096010. [DOI] [PubMed] [Google Scholar]
- Kanski J. J. Care of children with anterior uveitis. Trans Ophthalmol Soc U K. 1981 Sep;101(3):387–390. [PubMed] [Google Scholar]
- Kanski J. J., Shun-Shin G. A. Systemic uveitis syndromes in childhood: an analysis of 340 cases. Ophthalmology. 1984 Oct;91(10):1247–1252. doi: 10.1016/s0161-6420(84)34177-x. [DOI] [PubMed] [Google Scholar]
- Kazdan J. J., McCulloch J. C., Crawford J. S. Uveitis in children. Can Med Assoc J. 1967 Feb 18;96(7):385–391. [PMC free article] [PubMed] [Google Scholar]
- Key S. N., 3rd, Kimura S. J. Iridocyclitis associated with juvenile rheumatoid arthritis. Am J Ophthalmol. 1975 Sep;80(3 Pt 1):425–429. doi: 10.1016/0002-9394(75)90529-2. [DOI] [PubMed] [Google Scholar]
- Kimura S. J., Hogan M. J., O'Connor G. R., Epstein W. V. Uveitis and joint diseases. Clinical findings in 191 cases. Arch Ophthalmol. 1967 Mar;77(3):309–316. doi: 10.1001/archopht.1967.00980020311004. [DOI] [PubMed] [Google Scholar]
- Ohno S., Char D. H., Kimura S. J., O'Connor G. R. HLA antigens and antinuclear antibody titres in juvenile chronic iridocyclitis. Br J Ophthalmol. 1977 Jan;61(1):59–61. doi: 10.1136/bjo.61.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perkins E. S. Pattern of uveitis in children. Br J Ophthalmol. 1966 Apr;50(4):169–185. doi: 10.1136/bjo.50.4.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMILEY W. K., MAY E., BYWATERS E. G. Ocular presentations of Still's disease and their treatment: iridocyclitis in Still's disease: its complications and treatment. Ann Rheum Dis. 1957 Sep;16(3):371–383. doi: 10.1136/ard.16.3.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schaller J. G., Johnson G. D., Holborow E. J., Ansell B. M., Smiley W. K. The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease). Arthritis Rheum. 1974 Jul-Aug;17(4):409–416. doi: 10.1002/art.1780170411. [DOI] [PubMed] [Google Scholar]
- Schaller J., Wedgwood R. J. Juvenile rheumatoid arthritis: a review. Pediatrics. 1972 Dec;50(6):940–953. [PubMed] [Google Scholar]
- Smiley W. K. Iridocyclitis in Still's disease. Prognosis and steroid treatment. Trans Ophthalmol Soc U K. 1965;85:351–356. [PubMed] [Google Scholar]
- Smiley W. K. The eye in juvenile rheumatoid arthritis. Trans Ophthalmol Soc U K. 1974 Sep;94(3):817–829. [PubMed] [Google Scholar]
- Spalter H. F. The visual prognosis in juvenile rheumatoid arthritis. Trans Am Ophthalmol Soc. 1975;73:554–570. [PMC free article] [PubMed] [Google Scholar]
- Stewart A. J., Hill R. H. Ocular manifestations in juvenile rheumatoid arthritis. Can J Ophthalmol. 1967 Jan;2(1):58–62. [PubMed] [Google Scholar]
- VESTERDAL E., SURY B. Iridocyclitis and bandshaped corneal opacity in juvenile rheumatoid arthritis. Acta Ophthalmol (Copenh) 1950;28(3):321–335. doi: 10.1111/j.1755-3768.1950.tb05365.x. [DOI] [PubMed] [Google Scholar]
- Wolf M. D., Lichter P. R., Ragsdale C. G. Prognostic factors in the uveitis of juvenile rheumatoid arthritis. Ophthalmology. 1987 Oct;94(10):1242–1248. doi: 10.1016/s0161-6420(87)80007-6. [DOI] [PubMed] [Google Scholar]