Abstract
We report for the first time to our knowledge the histopathological findings in the eye of a patient with type II mesangiocapillary glomerulonephritis (dense deposit disease) in which a deposit of material morphologically very similar to that which is pathognomonic for the disease in the kidney was demonstrated in Bruch's membrane. The nature of the deposit in the renal lesion is unknown but is considered to represent a structural alteration secondary to a reaction with anticomplement antibody. Clinically the fundus appearance resembled that seen in drusen.
Full text
PDF





Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aronson A. J., Ordoñez N. G., Diddie K. R., Ernest J. T. Immune-complex deposition in the eye in systemic lupus erythematosus. Arch Intern Med. 1979 Nov;139(11):1312–1313. [PubMed] [Google Scholar]
- Ashton N. The eye in malignant hypertension. Trans Am Acad Ophthalmol Otolaryngol. 1972 Jan-Feb;76(1):17–40. [PubMed] [Google Scholar]
- BUCHANAN W. S., ELLIS P. P. RETINAL SEPARATION IN CHRONIC GLOMERULONEPHRITIS. REPORT OF A PATIENT CURED BY BILATERAL NEPHRECTOMIES AND SUBSEQUENT SUCCESSFUL KIDNEY TRANSPLANT. Arch Ophthalmol. 1964 Feb;71:182–186. doi: 10.1001/archopht.1964.00970010198008. [DOI] [PubMed] [Google Scholar]
- Burkholder P. M., Hyman L. R., Krueger R. P. Characterization of mixed membranous and proliferative glomerulonephritis: recognition of three varieties. Perspect Nephrol Hypertens. 1973;1(Pt 1):557–589. [PubMed] [Google Scholar]
- Duvall J., Tso M. O. Cellular mechanisms of resolution of drusen after laser coagulation. An experimental study. Arch Ophthalmol. 1985 May;103(5):694–703. doi: 10.1001/archopht.1985.01050050086024. [DOI] [PubMed] [Google Scholar]
- Ellis P. P., Fonken H. A. Retinopathies of chronic glomerulonephritis. A study of cases treated with renal transplantation. Arch Ophthalmol. 1966 Jan;75(1):36–41. doi: 10.1001/archopht.1966.00970050038008. [DOI] [PubMed] [Google Scholar]
- Fastenberg D. M., Fetkenhour C. L., Choromokos E., Shoch D. E. Choroidal vascular changes in toxemia of pregnancy. Am J Ophthalmol. 1980 Mar;89(3):362–368. doi: 10.1016/0002-9394(80)90005-7. [DOI] [PubMed] [Google Scholar]
- Gitter K. A., Houser B. P., Sarin L. K., Justice J., Jr Toxemia of pregnancy. An angiographic interpretation of fundus changes. Arch Ophthalmol. 1968 Oct;80(4):449–454. doi: 10.1001/archopht.1968.00980050451008. [DOI] [PubMed] [Google Scholar]
- Gold D. H., Morris D. A., Henkind P. Ocular findings in systemic lupus erythematosus. Br J Ophthalmol. 1972 Nov;56(11):800–804. doi: 10.1136/bjo.56.11.800. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jampol L. M., Lahov M., Albert D. M., Craft J. Ocular clinical findings and basement membrane changes in Goodpasture's syndrome. Am J Ophthalmol. 1975 Mar;79(3):452–463. doi: 10.1016/0002-9394(75)90622-4. [DOI] [PubMed] [Google Scholar]
- Kishi S., Tso M. O., Hayreh S. S. Fundus lesions in malignant hypertension. I. A pathologic study of experimental hypertensive choroidopathy. Arch Ophthalmol. 1985 Aug;103(8):1189–1197. doi: 10.1001/archopht.1985.01050080101029. [DOI] [PubMed] [Google Scholar]
- Klien B. A. Ischemic infarcts of the choroid (Elschinig spots). A cause of retinal separation in hypertensive disease with renal insufficiency. A clinical and histopathologic study. Am J Ophthalmol. 1968 Dec;66(6):1069–1074. [PubMed] [Google Scholar]
- Nik N. A., Martin N. F., Berler D. K. Corneal crystalline deposits and drusenosis associated with IgA-kappa chain monoclonal gammopathy. Ann Ophthalmol. 1985 May;17(5):303-7, 310. [PubMed] [Google Scholar]
- Peress N. S., Miller F., Palu W. The immunopathophysiological effects of chronic serum sickness on rat choroid plexus, ciliary process and renal glomeruli. J Neuropathol Exp Neurol. 1977 Jul;36(4):726–733. doi: 10.1097/00005072-197707000-00007. [DOI] [PubMed] [Google Scholar]
- Pertschuk L. P., Szabo K., Vuletin J. C., Rainford E. A. Ocular immunopathology in murine lupus. Arch Pathol Lab Med. 1977 Mar;101(3):122–124. [PubMed] [Google Scholar]
- Pratt M. V., de Venecia G. Central retinal vein occlusion following peritoneal dialysis. Am J Ophthalmol. 1970 Sep;70(3):337–340. doi: 10.1016/0002-9394(70)90092-9. [DOI] [PubMed] [Google Scholar]
- Ramsell J. T., Ellis P. P., Paterson C. A. Intraocular pressure changes during hemodialysis. Am J Ophthalmol. 1971 Nov;72(5):926–930. doi: 10.1016/0002-9394(71)91690-4. [DOI] [PubMed] [Google Scholar]