Skip to main content
PMC home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1989 May;73(5):354–359. doi: 10.1136/bjo.73.5.354

Childhood leukaemia: relapse in the anterior segment of the eye.

P Novakovic 1, S J Kellie 1, D Taylor 1
PMCID: PMC1041738  PMID: 2730856

Abstract

A proved first relapse occurred in the anterior segment of eight children with acute leukaemia, two of whom had concurrent central nervous system or bone marrow relapse. A further child developed uveitis after remission was induced, but in this patient no causal relationship with leukaemia was established. Uveitis in children who have had acute leukaemia should be regarded as evidence of relapse, and anterior chamber aspiration and iris biopsy are essential procedures in their evaluation. The outlook for children with anterior segment relapse remains poor despite intensive local and systemic treatment.

Full text

PDF
354

Images in this article

355Image
on p.355
356Image
on p.356
356Image
on p.356

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLEN R. A., STRAATSMA B. R. Ocular involvement in leukemia and allied disorders. Arch Ophthalmol. 1961 Oct;66:490–508. doi: 10.1001/archopht.1961.00960010492010. [DOI] [PubMed] [Google Scholar]
  2. Abramson D. H., Wachtel A., Watson C. W., Jereb B., Wollner N. Leukemic hypopyon. J Pediatr Ophthalmol Strabismus. 1981 May-Jun;18(3):42–44. doi: 10.3928/0191-3913-19810501-10. [DOI] [PubMed] [Google Scholar]
  3. Behrendt H., Wenniger-Prick L. M. Leukemic iris infiltration as the only site of relapse in a child with acute lymphoblastic leukemia: temporary remission with high-dose chemotherapy. Med Pediatr Oncol. 1985;13(6):352–356. doi: 10.1002/mpo.2950130610. [DOI] [PubMed] [Google Scholar]
  4. Bremner M. H., Wright J. Ocular leukaemia in acute lymphoblastic leukaemia of childhood. Aust J Ophthalmol. 1982 Nov;10(4):255–262. doi: 10.1111/j.1442-9071.1982.tb01626.x. [DOI] [PubMed] [Google Scholar]
  5. Bunin N., Rivera G., Goode F., Hustu H. O. Ocular relapse in the anterior chamber in childhood acute lymphoblastic leukemia. J Clin Oncol. 1987 Feb;5(2):299–303. doi: 10.1200/JCO.1987.5.2.299. [DOI] [PubMed] [Google Scholar]
  6. Crompton J. L., Taylor D. Ocular lesions in the blue rubber bleb naevus syndrome. Br J Ophthalmol. 1981 Feb;65(2):133–137. doi: 10.1136/bjo.65.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DEITCH R. D., WILSON F. M. Leukemic reticuloendotheliosis with presenting ocular complaints. Report of a case. Arch Ophthalmol. 1963 May;69:560–563. doi: 10.1001/archopht.1963.00960040566005. [DOI] [PubMed] [Google Scholar]
  8. Elliott A. J., Oakhill A., Goodman S. Cataracts in childhood leukaemia. Br J Ophthalmol. 1985 Jun;69(6):459–461. doi: 10.1136/bjo.69.6.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fonken H. A., Ellis P. P. Leukemic infiltrates in the iris. Successful treatment of secondary glaucoma with x-irradiation. Arch Ophthalmol. 1966 Jul;76(1):32–36. doi: 10.1001/archopht.1966.03850010034009. [DOI] [PubMed] [Google Scholar]
  10. Glaser B., Smith J. L. Leukaemic glaucoma. Br J Ophthalmol. 1966 Feb;50(2):92–94. doi: 10.1136/bjo.50.2.92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gruenewald R. L., Perry M. C., Henry P. H. Leukemic iritis with hypopyon. Cancer. 1979 Oct;44(4):1511–1513. doi: 10.1002/1097-0142(197910)44:4<1511::aid-cncr2820440449>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  12. Guzak S. V., Jr Lymphoma as a cause of hyphema. Arch Ophthalmol. 1970 Aug;84(2):229–231. doi: 10.1001/archopht.1970.00990040231018. [DOI] [PubMed] [Google Scholar]
  13. Hinzpeter E. N., Knöbel H., Freund J. Spontaneous haemophthalmus in leukaemia. Ophthalmologica. 1978;177(4):224–228. doi: 10.1159/000308770. [DOI] [PubMed] [Google Scholar]
  14. Holbrook C. T., Elsas F. J., Crist W. M., Castleberry R. P. Acute leukemia and hypopyon. J Pediatr. 1978 Oct;93(4):626–628. doi: 10.1016/s0022-3476(78)80902-0. [DOI] [PubMed] [Google Scholar]
  15. Jankovic M., Masera G., Uderzo C., Cattoretti G., Conter V., Ceppellini C., Miglior M., Lasagni F., Lambertenghi E., Parravicini C. Recurrences of isolated leukemic hypopyon in a child with acute lymphoblastic leukemia. Cancer. 1986 Jan 15;57(2):380–384. doi: 10.1002/1097-0142(19860115)57:2<380::aid-cncr2820570232>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  16. Johnston S. S., Ware C. F. Iris involvement in leukaemia. Br J Ophthalmol. 1973 May;57(5):320–324. doi: 10.1136/bjo.57.5.320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kincaid M. C., Green W. R. Ocular and orbital involvement in leukemia. Surv Ophthalmol. 1983 Jan-Feb;27(4):211–232. doi: 10.1016/0039-6257(83)90123-6. [DOI] [PubMed] [Google Scholar]
  18. Krebs W., Metz O., Plenert W. Okuläre Symptomatik und Leukämie im Kindesalter. Klin Monbl Augenheilkd. 1982 Nov;181(5):407–408. doi: 10.1055/s-2008-1055260. [DOI] [PubMed] [Google Scholar]
  19. Lin H. P., Chandran S., Tan M. K., Sinniah D. Hypopyon--an early sign of leukaemic relapse. Med Pediatr Oncol. 1980;8(1):97–100. doi: 10.1002/mpo.2950080113. [DOI] [PubMed] [Google Scholar]
  20. Mark L. E., Rouhani J., Sawitsky A. Leukemic iris infiltration in a case of meningeal leukemia. Ann Ophthalmol. 1974 Jul;6(7):669–674. [PubMed] [Google Scholar]
  21. Ninane J., Taylor D., Day S. The eye as a sanctuary in acute lymphoblastic leukaemia. Lancet. 1980 Mar 1;1(8166):452–453. doi: 10.1016/s0140-6736(80)90999-x. [DOI] [PubMed] [Google Scholar]
  22. Perry H. D., Mallen F. J. Iris involvement in granulocytic sarcoma. Am J Ophthalmol. 1979 Apr;87(4):530–532. doi: 10.1016/0002-9394(79)90243-5. [DOI] [PubMed] [Google Scholar]
  23. Pinkerton C. R., Bowman A., Holtzel H., Chessells J. M. Intensive consolidation chemotherapy for acute lymphoblastic leukaemia (UKALL X pilot study). Arch Dis Child. 1987 Jan;62(1):12–18. doi: 10.1136/adc.62.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ridgway E. W., Jaffe N., Walton D. S. Leukemic ophthalmopathy in children. Cancer. 1976 Oct;38(4):1744–1749. doi: 10.1002/1097-0142(197610)38:4<1744::aid-cncr2820380449>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  25. Robb R. M., Ervin L. D., Sallan S. E. An autopsy study of eye involvement in acute leukemia of childhood. Med Pediatr Oncol. 1979;6(2):171–177. doi: 10.1002/mpo.2950060210. [DOI] [PubMed] [Google Scholar]
  26. Rowan P. J., Sloan J. B. Iris and anterior chamber involvement in leukemia. Ann Ophthalmol. 1976 Sep;8(9):1081–1085. [PubMed] [Google Scholar]
  27. Tabbara K. F., Beckstead J. H. Acute promonocytic leukemia with ocular involvement. Arch Ophthalmol. 1980 Jun;98(6):1055–1058. doi: 10.1001/archopht.1980.01020031045006. [DOI] [PubMed] [Google Scholar]
  28. Zakka K. A., Yee R. D., Shorr N., Smith G. S., Pettit T. H., Foos R. Y. Leukemic iris infiltration. Am J Ophthalmol. 1980 Feb;89(2):204–209. doi: 10.1016/0002-9394(80)90112-9. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES