Skip to main content
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1989 Jul;73(7):552–554. doi: 10.1136/bjo.73.7.552

Subepithelial corneal deposits in IgG lambda myeloma.

J C Hill 1, G P Mulligan 1
PMCID: PMC1041799  PMID: 2503029

Abstract

A 46-year-old female presented with disseminated IgG lambda myeloma and unusual, translucent, subepithelial deposits in the periphery of both corneas. Electrophoretic studies showed that the deposits consisted of an IgG lambda paraprotein identical to that found in the serum. Minute amounts of the papaprotein were also present in the tears.

Full text

PDF
552

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARONSON S. B., 2nd, SHAW R. Corneal crystals in multiple myeloma. AMA Arch Ophthalmol. 1959 Apr;61(4):541–546. doi: 10.1001/archopht.1959.00940090543007. [DOI] [PubMed] [Google Scholar]
  2. Barr C. C., Gelender H., Font R. L. Corneal crystalline deposits associated with dysproteinemia. Report of two cases and review of the literature. Arch Ophthalmol. 1980 May;98(5):884–889. doi: 10.1001/archopht.1980.01020030878015. [DOI] [PubMed] [Google Scholar]
  3. Eiferman R. A., Rodrigues M. M. Unusual superficial stromal corneal deposits in IgG kappa monoclonal gammopathy. Arch Ophthalmol. 1980 Jan;98(1):78–81. doi: 10.1001/archopht.1980.01020030080003. [DOI] [PubMed] [Google Scholar]
  4. FRANCOIS J., RABAEY M. Corneal dystrophy and paraproteinemia. Am J Ophthalmol. 1961 Dec;52:895–901. doi: 10.1016/0002-9394(61)90334-8. [DOI] [PubMed] [Google Scholar]
  5. Johnson A. M. Immunofixation electrophoresis and electrofocusing. Clin Chem. 1982 Aug;28(8):1797–1800. [PubMed] [Google Scholar]
  6. Klintworth G. K., Bredehoeft S. J., Reed J. W. Analysis of corneal crystalline deposits in multiple myeloma. Am J Ophthalmol. 1978 Sep;86(3):303–313. doi: 10.1016/0002-9394(78)90230-1. [DOI] [PubMed] [Google Scholar]
  7. Knapp A. J., Gartner S., Henkind P. Multiple myeloma and its ocular manifestations. Surv Ophthalmol. 1987 Mar-Apr;31(5):343–351. doi: 10.1016/0039-6257(87)90119-6. [DOI] [PubMed] [Google Scholar]
  8. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  9. Miller K. H., Green W. R., Stark W. J., Wells H. A., Mendelsohn G., Kanhofer H. Immunoprotein deposition in the cornea. Ophthalmology. 1980 Sep;87(9):944–950. doi: 10.1016/s0161-6420(80)35154-3. [DOI] [PubMed] [Google Scholar]
  10. Pinkerton R. M., Robertson D. M. Corneal and conjunctival changes in dysproteinemia. Invest Ophthalmol. 1969 Aug;8(4):357–364. [PubMed] [Google Scholar]
  11. Rodrigues M. M., Krachmer J. H., Miller S. D., Newsome D. A. Posterior corneal crystalline deposits in benign monoclonal gammopathy: a clinicopathologic case report. Arch Ophthalmol. 1979 Jan;97(1):124–128. doi: 10.1001/archopht.1979.01020010058014. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES