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[Preprint]. 2023 Aug 2:2023.08.02.551708. [Version 1] doi: 10.1101/2023.08.02.551708

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Fig 5 — Knockdown extent affects the sign of antibiotic-gene interactions. (A-B) Schematics of idealized dose-response curves showing monotonic or hormetic relationships between dose and response; hormetic responses change the sign of the response depending on dose. (C-D) Knockdown-response curves of glnS show a nearly monotonic response in the absence of IMI, but a hormetic response in the presence of IMI. (E) The interaction between the IleRS tRNA synthetase inhibitor mupirocin (MUP) and IMI shows a hormetic response at intermediate concentrations of IMI.