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. 1989 Aug;73(8):669–673. doi: 10.1136/bjo.73.8.669

Corneal subepithelial monoclonal kappa IgG deposits in essential cryoglobulinaemia.

I Kremer 1, P Wright 1, S Merin 1, J Weiss 1, A I Pick 1, H Kaufman 1
PMCID: PMC1041843  PMID: 2504274

Abstract

A 60-year-old man suffering from photophobia and visual disturbances was found to have bilateral superficial corneal grey-white gelatinous deposits. An abnormal cold-precipitable serum component was found and characterised as homogeneous IgG-kappa immunoglobulin. Corneal immunohistochemical examination revealed subepithelial IgG-kappa deposits, focally replacing Bowman's layer. The patient underwent superficial keratectomy in both eyes with satisfactory visual results.

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Selected References

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  1. ARONSON S. B., 2nd, SHAW R. Corneal crystals in multiple myeloma. AMA Arch Ophthalmol. 1959 Apr;61(4):541–546. doi: 10.1001/archopht.1959.00940090543007. [DOI] [PubMed] [Google Scholar]
  2. Allansmith M. R., McClellan B. H. Immunoglobulins in the human cornea. Am J Ophthalmol. 1975 Jul;80(1):123–132. doi: 10.1016/0002-9394(75)90882-x. [DOI] [PubMed] [Google Scholar]
  3. Allansmith M. R., Whitney C. R., McClellan B. H., Newman L. P. Immunoglobulins in the human eye. Location, type, and amount. Arch Ophthalmol. 1973 Jan;89(1):36–45. doi: 10.1001/archopht.1973.01000040038010. [DOI] [PubMed] [Google Scholar]
  4. BURKI E. Uber Hornhautveränderungen bei einem Fall von multiplem Myelom (Plasmocytom). Ophthalmologica. 1958 May-Jun;135(5-6):565–572. doi: 10.1159/000303353. [DOI] [PubMed] [Google Scholar]
  5. Barr C. C., Gelender H., Font R. L. Corneal crystalline deposits associated with dysproteinemia. Report of two cases and review of the literature. Arch Ophthalmol. 1980 May;98(5):884–889. doi: 10.1001/archopht.1980.01020030878015. [DOI] [PubMed] [Google Scholar]
  6. Eiferman R. A., Rodrigues M. M. Unusual superficial stromal corneal deposits in IgG kappa monoclonal gammopathy. Arch Ophthalmol. 1980 Jan;98(1):78–81. doi: 10.1001/archopht.1980.01020030080003. [DOI] [PubMed] [Google Scholar]
  7. FRANCOIS J., RABAEY M. Corneal dystrophy and paraproteinemia. Am J Ophthalmol. 1961 Dec;52:895–901. doi: 10.1016/0002-9394(61)90334-8. [DOI] [PubMed] [Google Scholar]
  8. Firkin F. C., Lee N., Ramsay R., Robertson I. Visual loss caused by corneal crystals in myeloma: rapid improvement and plasma exchange and chemotherapy. Med J Aust. 1979 Dec 29;2(13):677–678. doi: 10.5694/j.1326-5377.1979.tb104268.x. [DOI] [PubMed] [Google Scholar]
  9. Francois J. Paraproteinaemic thesaurismosis of the cornea in Kahler's multiple myelomatosis. Eye Ear Nose Throat Mon. 1967 Jul;46(7):857–passim. [PubMed] [Google Scholar]
  10. Klintworth G. K., Bredehoeft S. J., Reed J. W. Analysis of corneal crystalline deposits in multiple myeloma. Am J Ophthalmol. 1978 Sep;86(3):303–313. doi: 10.1016/0002-9394(78)90230-1. [DOI] [PubMed] [Google Scholar]
  11. Laibson P. R. X-ray and electron diffraction of ocular and bone marrow crystals in paraproteinemia. Science. 1969 Feb 7;163(3867):581–583. doi: 10.1126/science.163.3867.581. [DOI] [PubMed] [Google Scholar]
  12. Miller K. H., Green W. R., Stark W. J., Wells H. A., Mendelsohn G., Kanhofer H. Immunoprotein deposition in the cornea. Ophthalmology. 1980 Sep;87(9):944–950. doi: 10.1016/s0161-6420(80)35154-3. [DOI] [PubMed] [Google Scholar]
  13. OGLESBY R. B. Corneal opacities in a patient with cryoglobulinemia and reticulohistiocytosis. Arch Ophthalmol. 1961 Jan;65:63–66. doi: 10.1001/archopht.1961.01840020065013. [DOI] [PubMed] [Google Scholar]
  14. Ormerod L. D., Collin H. B., Dohlman C. H., Craft J. L., Desforges J. F., Albert D. M. Paraproteinemic crystalline keratopathy. Ophthalmology. 1988 Feb;95(2):202–212. doi: 10.1016/s0161-6420(88)33200-8. [DOI] [PubMed] [Google Scholar]
  15. Pinkerton R. M., Robertson D. M. Corneal and conjunctival changes in dysproteinemia. Invest Ophthalmol. 1969 Aug;8(4):357–364. [PubMed] [Google Scholar]
  16. Rodrigues M. M., Krachmer J. H., Miller S. D., Newsome D. A. Posterior corneal crystalline deposits in benign monoclonal gammopathy: a clinicopathologic case report. Arch Ophthalmol. 1979 Jan;97(1):124–128. doi: 10.1001/archopht.1979.01020010058014. [DOI] [PubMed] [Google Scholar]

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