Abstract
The efficacy of 1.0% apraclonidine (para-aminoclonidine) in preventing the rise of intraocular pressure following anterior segment, laser surgery was evaluated in a randomised double-masked study. Ninety-nine consecutive patients requiring laser treatment of the anterior segment were included in the study. They were randomised into two groups, one receiving 1.0% para-aminoclonidine and the other placebo (vehicle of para-aminoclonidine). The drug caused a statistically significant reduction in pressure after the laser treatment without causing clinically significant side effects such as bradycardia or hypotension.
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- Flohr M. J., Robin A. L., Kelley J. S. Early complications following Q-switched neodymium: YAG laser posterior capsulotomy. Ophthalmology. 1985 Mar;92(3):360–363. doi: 10.1016/s0161-6420(85)34026-5. [DOI] [PubMed] [Google Scholar]
- Gharagozloo N. Z., Relf S. J., Brubaker R. F. Aqueous flow is reduced by the alpha-adrenergic agonist, apraclonidine hydrochloride (ALO 2145). Ophthalmology. 1988 Sep;95(9):1217–1220. doi: 10.1016/s0161-6420(88)33038-1. [DOI] [PubMed] [Google Scholar]
- Henry J. C., Krupin T., Schultz J., Wax M. Increased intraocular pressure following neodymium-YAG laser iridectomy. Arch Ophthalmol. 1986 Feb;104(2):178–178. doi: 10.1001/archopht.1986.01050140030010. [DOI] [PubMed] [Google Scholar]
- Hotchkiss M. L., Robin A. L., Pollack I. P., Quigley H. A. Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty. A trial with flurbiprofen and indomethacin. Ophthalmology. 1984 Aug;91(8):969–976. doi: 10.1016/s0161-6420(84)34218-x. [DOI] [PubMed] [Google Scholar]
- Pollack I. P., Brown R. H., Crandall A. S., Robin A. L., Stewart R. H., White G. L. Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical 1% apraclonidine. Arch Ophthalmol. 1988 Jun;106(6):754–757. doi: 10.1001/archopht.1988.01060130824031. [DOI] [PubMed] [Google Scholar]
- Robin A. L., Pollack I. P. A comparison of neodymium: YAG and argon laser iridotomies. Ophthalmology. 1984 Sep;91(9):1011–1016. doi: 10.1016/s0161-6420(84)34199-9. [DOI] [PubMed] [Google Scholar]
- Robin A. L., Pollack I. P., House B., Enger C. Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty. Arch Ophthalmol. 1987 May;105(5):646–650. doi: 10.1001/archopht.1987.01060050064039. [DOI] [PubMed] [Google Scholar]
- Robin A. L., Pollack I. P., deFaller J. M. Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy. Arch Ophthalmol. 1987 Sep;105(9):1208–1211. doi: 10.1001/archopht.1987.01060090066029. [DOI] [PubMed] [Google Scholar]
- Rouot B. R., Snyder S. H. [3H]Para-amino-clonidine: a novel ligand which binds with high affinity to alpha-adrenergic receptors. Life Sci. 1979 Aug 27;25(9):769–774. doi: 10.1016/0024-3205(79)90521-6. [DOI] [PubMed] [Google Scholar]
- Schrems W., Eichelbrönner O., Krieglstein G. K. The immediate IOP response of Nd-YAG-laser iridotomy and its prophylactic treatability. Acta Ophthalmol (Copenh) 1984 Oct;62(5):673–680. doi: 10.1111/j.1755-3768.1984.tb05794.x. [DOI] [PubMed] [Google Scholar]
- Terry A. C., Stark W. J., Maumenee A. E., Fagadau W. Neodymium-YAG laser for posterior capsulotomy. Am J Ophthalmol. 1983 Dec;96(6):716–720. doi: 10.1016/s0002-9394(14)71912-9. [DOI] [PubMed] [Google Scholar]
- Weinreb R. N., Ruderman J., Juster R., Zweig K. Immediate intraocular pressure response to argon laser trabeculoplasty. Am J Ophthalmol. 1983 Mar;95(3):279–286. doi: 10.1016/s0002-9394(14)78294-7. [DOI] [PubMed] [Google Scholar]