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. 1990 Aug;74(8):458–461. doi: 10.1136/bjo.74.8.458

Oral fluorescein angiography: reassessment of its relative safety and evaluation of optimum conditions with use of capsules.

A P Watson 1, E S Rosen 1
PMCID: PMC1042172  PMID: 2390518

Abstract

Injection of fluorescein intravenously for fundal angiography is associated with a high incidence of minor adverse effects (21%) but a very low incidence of serious (life threatening) reactions (0.05%). A serious reaction may occur without warning in a patient with no history of atopy. There are no reports of oral fluorescein causing a serious reaction, and minor adverse effects are uncommon. A study was undertaken to determine optimum conditions for oral fluorescein angiography. Capsules proved more convenient than a solution for ingestion of fluorescein. A dose of 25 mg/kg body weight produced good quality angiograms in 75% of the patients. The best pictures were obtained by photographing the fundus after 40 and 60 minutes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arroyave C. M., Wolbers R., Ellis P. P. Plasma complement and histamine changes after intravenous administration of sodium fluorescein. Am J Ophthalmol. 1979 Apr;87(4):474–479. doi: 10.1016/0002-9394(79)90233-2. [DOI] [PubMed] [Google Scholar]
  2. Azad R., Nayak B. K., Tewari H. K., Khosla P. K. Oral fluorescein angiography. Indian J Ophthalmol. 1984 Sep-Oct;32(5):415–417. [PubMed] [Google Scholar]
  3. Butner R. W., McPherson A. R. Adverse reactions in intravenous fluorescein angiography. Ann Ophthalmol. 1983 Nov;15(11):1084–1086. [PubMed] [Google Scholar]
  4. Bynke H. G., Aberg L. Differentiation of papilloedema from pseudo-papilloedema by fluorescein ophthalmoscopy. Acta Ophthalmol (Copenh) 1970;48(4):752–758. [PubMed] [Google Scholar]
  5. Elman M. J., Fine S. L., Sorenson J., Yannuzzi L., Hoopes J., Weidenthal D. T., Singerman L. J. Skin necrosis following fluorescein extravasation. A survey of the Macula Society. Retina. 1987 Summer;7(2):89–93. [PubMed] [Google Scholar]
  6. Eustace P., Travers S., Mooney D. Oral fluorescein angiography in disc oedema. Bull Soc Belge Ophtalmol. 1984;211:35–41. [PubMed] [Google Scholar]
  7. Ghose S., Nayak B. K. Role of oral fluorescein in the diagnosis of early papilloedema in children. Br J Ophthalmol. 1987 Dec;71(12):910–915. doi: 10.1136/bjo.71.12.910. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hess J. B., Pacurariu R. I. Acute pulmonary edema following intravenous fluorescein angiography. Am J Ophthalmol. 1976 Oct;82(4):567–570. doi: 10.1016/0002-9394(76)90543-2. [DOI] [PubMed] [Google Scholar]
  9. Jacob J. S., Rosen E. S., Young E. Report on the presence of a toxic substance, dimethyl formamide, in sodium fluorescein used for fluorescein angiography. Br J Ophthalmol. 1982 Sep;66(9):567–568. doi: 10.1136/bjo.66.9.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Karhunen U., Raitta C., Kala R. Adverse reactions to fluorescein angiography. Acta Ophthalmol (Copenh) 1986 Jun;64(3):282–286. doi: 10.1111/j.1755-3768.1986.tb06919.x. [DOI] [PubMed] [Google Scholar]
  11. Kelley J. S., Kincaid M., Hoover R. E., McBeth C. Retinal fluorograms using oral fluorescein. Ophthalmology. 1980 Aug;87(8):805–811. doi: 10.1016/s0161-6420(80)35159-2. [DOI] [PubMed] [Google Scholar]
  12. Kelley J. S., Kincaid M. Retinal fluorography using oral fluorescein. Arch Ophthalmol. 1979 Dec;97(12):2331–2332. doi: 10.1001/archopht.1979.01020020547007. [DOI] [PubMed] [Google Scholar]
  13. Kirson L. E., Wilson M. E. Atrial fibrillation associated with intravenous fluorescein. Anesth Analg. 1987 Mar;66(3):283–283. doi: 10.1213/00000539-198703000-00018. [DOI] [PubMed] [Google Scholar]
  14. Morgan K. S., Franklin R. M. Oral fluorescein angioscopy in aphakic children. J Pediatr Ophthalmol Strabismus. 1984 Jan-Feb;21(1):33–36. doi: 10.3928/0191-3913-19840101-09. [DOI] [PubMed] [Google Scholar]
  15. Noble M. J., Cheng H., Jacobs P. M. Oral fluorescein and cystoid macular oedema: detection in aphakic and pseudophakic eyes. Br J Ophthalmol. 1984 Apr;68(4):221–224. doi: 10.1136/bjo.68.4.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Yannuzzi L. A., Rohrer K. T., Tindel L. J., Sobel R. S., Costanza M. A., Shields W., Zang E. Fluorescein angiography complication survey. Ophthalmology. 1986 May;93(5):611–617. doi: 10.1016/s0161-6420(86)33697-2. [DOI] [PubMed] [Google Scholar]

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