Skip to main content
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1990 Nov;74(11):647–649. doi: 10.1136/bjo.74.11.647

Intraocular pressure changes and postural changes of intraocular pressure in experimentally induced Hansen's disease of rhesus, mangabey, and African green monkeys.

N Hussein 1, B Ostler 1, B J Gormus 1, R Wolf 1, G P Walsh 1
PMCID: PMC1042249  PMID: 2223699

Abstract

In our long term evaluation of patients with Hansen's disease we have frequently found reduction of their intraocular pressure. Furthermore, we noted changes in their intraocular pressure on change of posture. To determine if these changes have any significance we measured the intraocular pressures of 24 experimentally infected and 39 control monkeys in both sitting and reclining positions. We found significant reduction of intraocular pressure in 66.7% compared with controls in the sitting position, and a significant increase in intraocular pressure in 79% when checked first in the sitting then in the reclining position. We offer a possible pathophysiological explanation as to why the changes occur.

Full text

PDF
647

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLEN J. H., BYERS J. L. The pathology of ocular leprosy. I. Cornea. Arch Ophthalmol. 1960 Aug;64:216–220. doi: 10.1001/archopht.1960.01840010218007. [DOI] [PubMed] [Google Scholar]
  2. COLLINS E. M., HOLLAND M. G., VON SALLMANN L. A study of the innervation of the chamber angle. Am J Ophthalmol. 1956 Oct;42(4 Pt 2):148–161. doi: 10.1016/0002-9394(56)90365-8. [DOI] [PubMed] [Google Scholar]
  3. Ffytche T. J. Role of iris changes as a cause of blindness in lepromatous leprosy. Br J Ophthalmol. 1981 Apr;65(4):231–239. doi: 10.1136/bjo.65.4.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ffytche T. J. The eye and leprosy. Lepr Rev. 1981 Jun;52(2):111–119. doi: 10.5935/0305-7518.19810012. [DOI] [PubMed] [Google Scholar]
  5. GREAVES D. P., PERKINS E. S. Influence of the sympathetic nervous system on the intra-ocular pressure and vascular circulation of the eye. Br J Ophthalmol. 1952 May;36(5):258–264. doi: 10.1136/bjo.36.5.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HASHIZUME H., SHIONUMA E. ELECTRON MICROSCOPIC STUDY OF LEPROMATOUS CHANGES IN THE IRIS. Int J Lepr. 1965 Jan-Mar;33:61–82. [PubMed] [Google Scholar]
  7. Hussein N., Courtright P., Ostler H. B., Hetherington J., Gelber R. H. Low intraocular pressure and postural changes in intraocular pressure in patients with Hansen's disease. Am J Ophthalmol. 1989 Jul 15;108(1):80–83. doi: 10.1016/s0002-9394(14)73265-9. [DOI] [PubMed] [Google Scholar]
  8. Martin L. N., Gormus B. J., Wolf R. H., Walsh G. P., Meyers W. M., Binford C. H., Harboe M. Experimental leprosy in nonhuman primates. Adv Vet Sci Comp Med. 1984;28:201–236. doi: 10.1016/b978-0-12-039228-5.50012-7. [DOI] [PubMed] [Google Scholar]
  9. Meyers W. M., Walsh G. P., Brown H. L., Binford C. H., Imes G. D., Jr, Hadfield T. L., Schlagel C. J., Fukunishi Y., Gerone P. J., Wolf R. H. Leprosy in a mangabey monkey--naturally acquired infection. Int J Lepr Other Mycobact Dis. 1985 Mar;53(1):1–14. [PubMed] [Google Scholar]
  10. Slem G. Clinical studies of ocular leprosy. Am J Ophthalmol. 1971 Jan;71(1 Pt 2):431–434. doi: 10.1016/0002-9394(71)90423-5. [DOI] [PubMed] [Google Scholar]
  11. Spaide R., Nattis R., Lipka A., D'Amico R. Ocular findings in leprosy in the United States. Am J Ophthalmol. 1985 Sep 15;100(3):411–416. doi: 10.1016/0002-9394(85)90503-3. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES