Abstract
An 81-year-old man developed hyperkalaemic and hyperchloraemic metabolic acidosis following treatment with a carbonic anhydrase inhibitor for his glaucoma. He had mild renal failure and selective aldosterone deficiency was confirmed. In this case the treatment did not lead to hypokalaemia because of the limited potassium secretory capacity in the renal tubules from selective aldosterone deficiency; rather, it may have led to hyperkalaemia because metabolic acidosis induced by the carbonic anhydrase inhibitor caused transcellular movement of potassium.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Epstein D. L., Grant W. M. Carbonic anhydrase inhibitor side effects. Serum chemical analysis. Arch Ophthalmol. 1977 Aug;95(8):1378–1382. doi: 10.1001/archopht.1977.04450080088009. [DOI] [PubMed] [Google Scholar]
- Heller I., Halevy J., Cohen S., Theodor E. Significant metabolic acidosis induced by acetazolamide. Not a rare complication. Arch Intern Med. 1985 Oct;145(10):1815–1817. [PubMed] [Google Scholar]
- Maisey D. N., Brown R. D. Acetazolamide and symptomatic metabolic acidosis in mild renal failure. Br Med J (Clin Res Ed) 1981 Dec 5;283(6305):1527–1528. doi: 10.1136/bmj.283.6305.1527. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sebastian A., McSherry E., Morris R. C., Jr Renal potassium wasting in renal tubular acidosis (RTA): its occurrence in types 1 and 2 RTA despite sustained correction of systemic acidosis. J Clin Invest. 1971 Mar;50(3):667–678. doi: 10.1172/JCI106537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sebastian A., Schambelan M., Lindenfeld S., Morris R. C., Jr Amelioration of metabolic acidosis with fludrocortisone therapy in hyporeninemic hypoaldosteronism. N Engl J Med. 1977 Sep 15;297(11):576–583. doi: 10.1056/NEJM197709152971104. [DOI] [PubMed] [Google Scholar]
- Swenson E. R. Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist. Arch Intern Med. 1986 Jun;146(6):1220–1221. [PubMed] [Google Scholar]