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. Author manuscript; available in PMC: 2023 Aug 12.
Published in final edited form as: Nature. 2023 Jul 19;619(7971):860–867. doi: 10.1038/s41586-023-06324-w

Extended Data Figure 1: Histological features of AT1- and AT2-derived lung adenomas.

Extended Data Figure 1:

(a) H&E stains of Hopx-ER>KRASG12D and Sftpc-ER-rtTA>KRASG12D mouse lungs at 5m14d and 1m22d after Kras induction, respectively, showing examples of the lepidic-predominant histology of AT1 derived adenomas (top) and the non-lepidic histology of AT2 derived adenomas (bottom). Note massive macrophage infiltration of the alveolar lumens in the lepidic AT1 tumors that extend multiple alveolar spaces beyond the solid AT2 tumors. (b) H&E stains showing examples of human lepidic and non-lepidic KRAS-driven LuAds. (c) Exemplary H&E stains of histological classifications of AT1- and AT2-derived tumors as quantified in the body of the manuscript.

Scale bars, 200 μm (a, c) and 400 μm (b)