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. 1991 Apr;75(4):229–231. doi: 10.1136/bjo.75.4.229

Influence of genotype on the natural history of untreated proliferative sickle retinopathy--an angiographic study.

P D Fox 1, S J Vessey 1, M L Forshaw 1, G R Serjeant 1
PMCID: PMC1042329  PMID: 2021592

Abstract

The natural history of untreated proliferative sickle retinopathy (PSR) has been observed in 35 patients (40 eyes) with homozygous sickle cell (SS) disease and in 112 patients (114 eyes) with sickle cell-haemoglobin C (SC) disease over a mean follow-up period of 4.5 years (range 0.5-14.0 years). In both genotypes progression of PSR was most frequent between ages 20 and 39 years. Spontaneous regression was more common in SS disease (p = 0.01), and more likely to proceed to complete non-perfusion. In SC disease PSR tended to be stable in patients aged 40 and over, and non-perfused PSR lesions were significantly more likely to reperfuse (p = 0.01) than in SS disease. In both genotypes regression was not influenced by size or elevation of the PSR lesion. The tendency for PSR to regress in SS disease suggests that treatment is unnecessary in SS patients aged 40 and over.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BETKE K., MARTI H. R., SCHLICHT I. Estimation of small percentages of foetal haemoglobin. Nature. 1959 Dec 12;184(Suppl 24):1877–1878. doi: 10.1038/1841877a0. [DOI] [PubMed] [Google Scholar]
  2. Condon P. I., Hayes R. J., Serjeant G. R. Retinal and choroidal neovascularization in sickle cell disease. Trans Ophthalmol Soc U K. 1980 Sep;100(3):434–439. [PubMed] [Google Scholar]
  3. Condon P. I., Jampol L. M., Ford S. M., Serjeant G. R. Choroidal neovascularisation induced by photocoagulation in sickle cell disease. Br J Ophthalmol. 1981 Mar;65(3):192–197. doi: 10.1136/bjo.65.3.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Condon P. I., Serjeant G. R. Behaviour of untreated proliferative sickle retinopathy. Br J Ophthalmol. 1980 Jun;64(6):404–411. doi: 10.1136/bjo.64.6.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Condon P. I., Serjeant G. R. Ocular findings in hemoglobin SC disease in Jamaica. Am J Ophthalmol. 1972 Nov;74(5):921–931. doi: 10.1016/0002-9394(72)91213-5. [DOI] [PubMed] [Google Scholar]
  6. Condon P. I., Serjeant G. R. Photocoagulation and diathermy in the treatment of proliferative sickle retinopathy. Br J Ophthalmol. 1974 Jul;58(7):650–662. doi: 10.1136/bjo.58.7.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Condon P. I., Serjeant G. R. The progression of sickle cell eye disease in Jamaica. Doc Ophthalmol. 1975 Nov 21;39(1):203–210. doi: 10.1007/BF00578763. [DOI] [PubMed] [Google Scholar]
  8. Cruess A. F., Stephens R. F., Magargal L. E., Brown G. C. Peripheral circumferential retinal scatter photocoagulation for treatment of proliferative sickle retinopathy. Ophthalmology. 1983 Mar;90(3):272–278. doi: 10.1016/s0161-6420(83)34577-2. [DOI] [PubMed] [Google Scholar]
  9. Galinos S. O., Asdourian G. K., Woolf M. B., Goldberg M. F., Busse B. J. Choroido-vitreal neovascularization after argon laser photocoagulation. Arch Ophthalmol. 1975 Jul;93(7):524–530. doi: 10.1001/archopht.1975.01010020540012. [DOI] [PubMed] [Google Scholar]
  10. Goldberg M. F., Acacio I. Argon laser photocoagulation of proliferative sickle retinopathy. Arch Ophthalmol. 1973 Jul;90(1):35–44. doi: 10.1001/archopht.1973.01000050037008. [DOI] [PubMed] [Google Scholar]
  11. Goldberg M. F. Natural history of untreated proliferative sickle retinopathy. Arch Ophthalmol. 1971 Apr;85(4):428–437. doi: 10.1001/archopht.1971.00990050430006. [DOI] [PubMed] [Google Scholar]
  12. Goldberg M. F. Treatment of proliferative sickle retinopathy. Trans Am Acad Ophthalmol Otolaryngol. 1971 May-Jun;75(3):532–556. [PubMed] [Google Scholar]
  13. Jampol L. M., Condon P., Farber M., Rabb M., Ford S., Serjeant G. A randomized clinical trial of feeder vessel photocoagulation of proliferative sickle cell retinopathy. I. Preliminary results. Ophthalmology. 1983 May;90(5):540–545. doi: 10.1016/s0161-6420(83)34537-1. [DOI] [PubMed] [Google Scholar]
  14. Kimmel A. S., Magargal L. E., Stephens R. F., Cruess A. F. Peripheral circumferential retinal scatter photocoagulation for the treatment of proliferative sickle retinopathy. An update. Ophthalmology. 1986 Nov;93(11):1429–1434. doi: 10.1016/s0161-6420(86)33549-8. [DOI] [PubMed] [Google Scholar]
  15. Lee C. B., Woolf M. B., Galinos S. O., Goldbaum M. H., Stevens T. S., Goldberg M. F. Cryotherapy of proliferative sickle retinopathy. Part I. Single freeze-thaw cycle. Ann Ophthalmol. 1975 Oct;7(10):1299–1308. [PubMed] [Google Scholar]
  16. Moriarty B. J., Acheson R. W., Condon P. I., Serjeant G. R. Patterns of visual loss in untreated sickle cell retinopathy. Eye (Lond) 1988;2(Pt 3):330–335. doi: 10.1038/eye.1988.62. [DOI] [PubMed] [Google Scholar]
  17. Nagpal K. C., Patrianakos D., Asdourian G. K., Goldberg M. F., Rabb M., Jampol L. Spontaneous regression (autoinfarction) of proliferative sickle retinopathy. Am J Ophthalmol. 1975 Nov;80(5):885–892. doi: 10.1016/0002-9394(75)90285-8. [DOI] [PubMed] [Google Scholar]
  18. Rednam K. R., Jampol L. M., Goldberg M. F. Scatter retinal photocoagulation for proliferative sickle cell retinopathy. Am J Ophthalmol. 1982 May;93(5):594–599. doi: 10.1016/s0002-9394(14)77374-x. [DOI] [PubMed] [Google Scholar]

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