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. 1991 May;75(5):311–312. doi: 10.1136/bjo.75.5.311

Clearance of corneal crystals in nephropathic cystinosis by topical cysteamine 0.5%.

N P Jones 1, R J Postlethwaite 1, J L Noble 1
PMCID: PMC1042364  PMID: 2036352

Abstract

A 2-year-old girl with nephropathic cystinosis was successfully treated with topical cysteamine 0.5% to one eye. Clearance of crystals from the treated cornea was virtually complete after three months. The possibilities and limitations of this form of treatment are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gahl W. A., Reed G. F., Thoene J. G., Schulman J. D., Rizzo W. B., Jonas A. J., Denman D. W., Schlesselman J. J., Corden B. J., Schneider J. A. Cysteamine therapy for children with nephropathic cystinosis. N Engl J Med. 1987 Apr 16;316(16):971–977. doi: 10.1056/NEJM198704163161602. [DOI] [PubMed] [Google Scholar]
  2. Jain S., Kuwabara T., Gahl W. A., Kaiser-Kupfer M. I. Range of toxicity of topical cysteamine in rabbit eyes. J Ocul Pharmacol. 1988 Summer;4(2):127–131. doi: 10.1089/jop.1988.4.127. [DOI] [PubMed] [Google Scholar]
  3. Kaiser-Kupfer M. I., Caruso R. C., Minkler D. S., Gahl W. A. Long-term ocular manifestations in nephropathic cystinosis. Arch Ophthalmol. 1986 May;104(5):706–711. doi: 10.1001/archopht.1986.01050170096030. [DOI] [PubMed] [Google Scholar]
  4. Kaiser-Kupfer M. I., Datiles M. B., Gahl W. A. Corneal transplant in boy with nephropathic cystinosis. Lancet. 1987 Feb 7;1(8528):331–331. doi: 10.1016/s0140-6736(87)92061-7. [DOI] [PubMed] [Google Scholar]
  5. Kaiser-Kupfer M. I., Fujikawa L., Kuwabara T., Jain S., Gahl W. A. Removal of corneal crystals by topical cysteamine in nephropathic cystinosis. N Engl J Med. 1987 Mar 26;316(13):775–779. doi: 10.1056/NEJM198703263161304. [DOI] [PubMed] [Google Scholar]
  6. Kaiser-Kupfer M. I., Gazzo M. A., Datiles M. B., Caruso R. C., Kuehl E. M., Gahl W. A. A randomized placebo-controlled trial of cysteamine eye drops in nephropathic cystinosis. Arch Ophthalmol. 1990 May;108(5):689–693. doi: 10.1001/archopht.1990.01070070075038. [DOI] [PubMed] [Google Scholar]
  7. Katz B., Melles R. B., Schneider J. A. Glare disability in nephropathic cystinosis. Arch Ophthalmol. 1987 Dec;105(12):1670–1671. doi: 10.1001/archopht.1987.01060120068026. [DOI] [PubMed] [Google Scholar]
  8. Katz B., Melles R. B., Schneider J. A. Recurrent crystal deposition after keratoplasty in nephropathic cystinosis. Am J Ophthalmol. 1987 Aug 15;104(2):190–191. doi: 10.1016/0002-9394(87)90018-3. [DOI] [PubMed] [Google Scholar]
  9. Melles R. B., Schneider J. A., Rao N. A., Katz B. Spatial and temporal sequence of corneal crystal deposition in nephropathic cystinosis. Am J Ophthalmol. 1987 Dec 15;104(6):598–604. doi: 10.1016/0002-9394(87)90171-1. [DOI] [PubMed] [Google Scholar]
  10. Truong T., Sagar S. M., Millard W. J., Shaw J. L. Cysteamine induces cataracts in newborn rats. Invest Ophthalmol Vis Sci. 1987 Oct;28(10):1710–1713. [PubMed] [Google Scholar]

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