Abstract
Lewis rats were immunised with retinal S-antigen to induce experimental autoimmune uveitis and experimental autoimmune pinealitis. The blood-retinal and blood-pineal 'barrier sites' were examined by transmission electron microscopy. Inflammatory cell movement through Bruch's membrane involved separation of its constituent layers, cell migration through pores in the membrane, and between retinal pigment epithelial cells without causing significant displacement of the retinal pigment epithelial cell layer. The endothelial cells of retinal and pineal vessels with perivascular infiltrates showed morphological features resembling endothelium of 'high endothelial venules'.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Al-Mahdawi S., Forrester J. V., Lee W. R. A simplified method for the isolation of highly purified bovine retinal S antigen. J Neuroimmunol. 1987 Feb;14(1):99–108. doi: 10.1016/0165-5728(87)90104-4. [DOI] [PubMed] [Google Scholar]
- Anderson N. D., Anderson A. O., Wyllie R. G. Specialized structure and metabolic activities of high endothelial venules in rat lymphatic tissues. Immunology. 1976 Sep;31(3):455–473. [PMC free article] [PubMed] [Google Scholar]
- De Kozak Y., Mirshahi M., Boucheix C., Faure J. P. Inhibition of experimental autoimmune uveoretinitis in rats by S-antigen-specific monoclonal antibodies. Eur J Immunol. 1985 Nov;15(11):1107–1111. doi: 10.1002/eji.1830151108. [DOI] [PubMed] [Google Scholar]
- Dua H. S., Liversidge J., Forrester J. V. Immunomodulation of experimental autoimmune uveitis using a rat anti retinal S-antigen specific monoclonal antibody: evidence for a species difference. Eye (Lond) 1989;3(Pt 1):69–78. doi: 10.1038/eye.1989.10. [DOI] [PubMed] [Google Scholar]
- Dua H. S., Sewell H. F., Forrester J. V. The effect of retinal S-antigen-specific monoclonal antibody therapy on experimental autoimmune uveoretinitis (EAU) and experimental autoimmune pinealitis (EAP). Clin Exp Immunol. 1989 Jan;75(1):100–105. [PMC free article] [PubMed] [Google Scholar]
- Duijvestijn A., Hamann A. Mechanisms and regulation of lymphocyte migration. Immunol Today. 1989 Jan;10(1):23–28. doi: 10.1016/0167-5699(89)90061-3. [DOI] [PubMed] [Google Scholar]
- Forrester J. V., Borthwick G. M., McMenamin P. G. Ultrastructural pathology of S-antigen uveoretinitis. Invest Ophthalmol Vis Sci. 1985 Sep;26(9):1281–1292. [PubMed] [Google Scholar]
- Forrester J. V., Liversidge J., Dua H. S., Towler H., McMenamin P. G. Comparison of clinical and experimental uveitis. Curr Eye Res. 1990;9 (Suppl):75–84. doi: 10.3109/02713689008999424. [DOI] [PubMed] [Google Scholar]
- Freemont A. J., Jones C. J., Bromley M., Andrews P. Changes in vascular endothelium related to lymphocyte collections in diseased synovia. Arthritis Rheum. 1983 Dec;26(12):1427–1433. doi: 10.1002/art.1780261203. [DOI] [PubMed] [Google Scholar]
- Freemont A. J. The small blood vessels in areas of lymphocytic infiltration around malignant neoplasms. Br J Cancer. 1982 Aug;46(2):283–288. doi: 10.1038/bjc.1982.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kalsow C. M., Wacker W. B. Pineal gland involvement in retina-induced experimental allergic uveitis. Invest Ophthalmol Vis Sci. 1978 Aug;17(8):774–783. [PubMed] [Google Scholar]
- Kraal G., Duijvestijn A. M., Hendriks H. H. The endothelium of the high endothelial venule: a specialized endothelium with unique properties. Exp Cell Biol. 1987;55(1):1–10. doi: 10.1159/000163388. [DOI] [PubMed] [Google Scholar]
- de Kozak Y., Thillaye B., Renard G., Faure J. P. Hyperacute form of experimental autoimmune uveo-retinitis in Lewis rats; electron microscopic study. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 8;208(1-3):135–142. doi: 10.1007/BF00406988. [DOI] [PubMed] [Google Scholar]