Skip to main content
The Journal of Biological Chemistry logoLink to The Journal of Biological Chemistry
. 2023 Aug 7;299(8):105125. doi: 10.1016/j.jbc.2023.105125

Withdrawal: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Huafeng Zhang, Marta Bosch-Marce, Larissa A Shimoda, Yee Sun Tan, Jin Hyen Baek, Jacob B Wesley, Frank J Gonzalez, Gregg L Semenza
PMCID: PMC10424196  PMID: 37556879

This article has been withdrawn by the authors, except F. Gonzalez who did not agree to this withdrawal notice, and J. B. Wesley who could not be reached. The withdrawing authors and journal concluded there were signs of background modifications in figure 3B corresponding to the 20% lane in the ‘KO-EV’ panel. Figure 4A presented background issues on the 20% lane of the ‘WT-EV’ panel. In figure 8A, in the ‘Anti-Bcl2’ top panel a band in the ‘IgG’ panel, ‘WT, 20%’ lane was potentially artificially removed. There were signs of duplication in the FACS plots in figure 9F. In supplemental figure S4, there were signs of potential splicing between lanes 2 and 3. Supplemental figure S5 presented signs of background manipulation on lane 1 on ‘Anti-Bcl2’ top panel. In supplemental figure S6 ‘WCL’ panel on the left, the ‘Anti-Bcl2’ top panel presented artificially deleted bands on lanes 1, 2, 5 and 6. In addition, in the ‘IP’ immunoblot panel on the right, lane 1 in anti-Flag top panel, the band was artificially removed. The ‘Anti-Bcl2’ panel at the bottom presented signs of inappropriate manipulation. The original data provided did not resolve these issues.

VOLUME 283 (2008) PAGES 10892–10903


Articles from The Journal of Biological Chemistry are provided here courtesy of American Society for Biochemistry and Molecular Biology

RESOURCES