Abstract
Retinopathy of prematurity (ROP) appears to be a multifactorial disease, the prevention of which is probably impossible even with the most accurate methods of blood-gas monitoring and oxygen restrictions. The oxidative processes and consequent formation of free radicals are probably influenced by the availability of various antioxidants in the immature retina. Bilirubin, the end product of haem catabolism, has recently been regarded as a potential physiological antioxidant. In order to test the suggestion as to the possible effect of bilirubin in reducing the incidence of ROP a retrospective study was undertaken of the medical records of 151 neonates born between 1984 to 1988 who weighed less than 1500 g. Of these, 78 had various degrees of ROP, whereas 73 had no ROP and served as a control group. The daily mean bilirubin values were analysed in accordance with gestational age and birth weight as well as the severity of ROP, and the results were compared with those obtained for the control group. The results showed no correlation between bilirubin levels and severity of ROP in all subgroups of gestational age and birth weight. These findings indicate that there is no apparent protective effect of bilirubin on the development of ROP.
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Selected References
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- Ben Sira I., Nissenkorn I., Kremer I. Retinopathy of prematurity. Surv Ophthalmol. 1988 Jul-Aug;33(1):1–16. doi: 10.1016/0039-6257(88)90068-9. [DOI] [PubMed] [Google Scholar]
- Gunn T. R., Easdown J., Outerbridge E. W., Aranda J. V. Risk factors in retrolental fibroplasia. Pediatrics. 1980 Jun;65(6):1096–1100. [PubMed] [Google Scholar]
- Heyman E., Ohlsson A., Girschek P. Retinopathy of prematurity and bilirubin. N Engl J Med. 1989 Jan 26;320(4):256–256. doi: 10.1056/NEJM198901263200420. [DOI] [PubMed] [Google Scholar]
- Kretzer F. L., Mehta R. S., Johnson A. T., Hunter D. G., Brown E. S., Hittner H. M. Vitamin E protects against retinopathy of prematurity through action on spindle cells. 1984 Jun 28-Jul 4Nature. 309(5971):793–795. doi: 10.1038/309793a0. [DOI] [PubMed] [Google Scholar]
- Lucey J. F., Dangman B. A reexamination of the role of oxygen in retrolental fibroplasia. Pediatrics. 1984 Jan;73(1):82–96. [PubMed] [Google Scholar]
- Phelps D. L. Vision loss due to retinopathy of prematurity. Lancet. 1981 Mar 14;1(8220 Pt 1):606–606. doi: 10.1016/s0140-6736(81)92047-x. [DOI] [PubMed] [Google Scholar]
- Saugstad O. D., Rognum T. O. High postmortem levels of hypoxanthine in the vitreous humor of premature babies with respiratory distress syndrome. Pediatrics. 1988 Mar;81(3):395–398. [PubMed] [Google Scholar]
- Shohat M., Reisner S. H., Krikler R., Nissenkorn I., Yassur Y., Ben-Sira I. Retinopathy of prematurity: incidence and risk factors. Pediatrics. 1983 Aug;72(2):159–163. [PubMed] [Google Scholar]
- Stocker R., Ames B. N. Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8130–8134. doi: 10.1073/pnas.84.22.8130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stocker R., Glazer A. N., Ames B. N. Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5918–5922. doi: 10.1073/pnas.84.16.5918. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stocker R., Yamamoto Y., McDonagh A. F., Glazer A. N., Ames B. N. Bilirubin is an antioxidant of possible physiological importance. Science. 1987 Feb 27;235(4792):1043–1046. doi: 10.1126/science.3029864. [DOI] [PubMed] [Google Scholar]